Changes in marrow adipose tissue with short-term changes in weight in premenopausal women with anorexia nervosa
| العنوان: | Changes in marrow adipose tissue with short-term changes in weight in premenopausal women with anorexia nervosa |
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| المؤلفون: | Stephen J Russell, Alexander T. Faje, Anne Klibanski, Miriam A. Bredella, Clifford J. Rosen, Sai P. Polineni, Pouneh K. Fazeli, Megi Resulaj |
| المصدر: | Eur J Endocrinol |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Bone mineral, medicine.medical_specialty, Longitudinal study, Bone density, business.industry, Endocrinology, Diabetes and Metabolism, Case-control study, Adipose tissue, 030209 endocrinology & metabolism, General Medicine, Article, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, medicine.anatomical_structure, Anorexia nervosa (differential diagnoses), 030220 oncology & carcinogenesis, Internal medicine, medicine, Bone marrow, medicine.symptom, business, Weight gain |
| الوصف: | Objective In anorexia nervosa, a psychiatric disease characterized by self-induced starvation and a model of chronic undernutrition, levels of subcutaneous (SAT) and visceral (VAT) adipose tissue are low, whereas marrow adipose tissue (MAT) levels are elevated compared to normal-weight women. The reason for this paradoxical elevation of an adipose tissue depot in starvation is not known. We sought to understand changes in MAT in response to subacute changes in weight and to compare these changes with those of other fat depots and body composition parameters. Design and methods We conducted a 12-month longitudinal study including 46 premenopausal women (n = 26 with anorexia nervosa and n = 20 normal-weight controls) with a mean (s.e.m.) age of 28.2 ± 0.8 years. We measured MAT, SAT, VAT and bone mineral density (BMD) at baseline and after 12 months. Results At baseline, SAT (P P P ≤ 0.0002) were significantly lower and vertebral and metaphyseal MAT (P ≤ 0.001) significantly higher in anorexia nervosa compared to controls. Weight gain over 12 months was associated with increases not only in SAT and VAT, but also epiphyseal MAT (P P Conclusions In contrast to the steady state, in which MAT levels are higher in anorexia nervosa and MAT and BMD are inversely associated, short-term weight gain is associated with increases in both MAT and BMD. These longitudinal data demonstrate the dynamic nature of this fat depot and provide further evidence of its possible role in mineral metabolism. |
| تدمد: | 1479-683X 0804-4643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a07d46a9ffd1a16eae03818ff5bcaa https://doi.org/10.1530/eje-18-0824 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c1a07d46a9ffd1a16eae03818ff5bcaa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1479683X 08044643 |
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