Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice
| العنوان: | Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice |
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| المؤلفون: | Martin Schwarzer, Umesh Kumar Gautam, Kassem Makki, Anne Lambert, Tomáš Brabec, Amélie Joly, Dagmar Šrůtková, Pierre Poinsot, Tereza Novotná, Stéphanie Geoffroy, Pascal Courtin, Petra Petr Hermanová, Renata C. Matos, Jonathan J. M. Landry, Céline Gérard, Anne-Laure Bulteau, Tomáš Hudcovic, Hana Kozáková, Dominik Filipp, Marie-Pierre Chapot-Chartier, Marek Šinkora, Noël Peretti, Ivo Gomperts Boneca, Mathias Chamaillard, Hubert Vidal, Filipe De Vadder, François Leulier |
| المساهمون: | Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| المصدر: | Science Science, 2023, 379 (6634), pp.826-833. ⟨10.1126/science.ade9767⟩ |
| بيانات النشر: | HAL CCSD, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Multidisciplinary, [SDV]Life Sciences [q-bio] |
| الوصف: | The intestinal microbiota is known to influence postnatal growth. We previously found that a strain of Lactiplantibacillus plantarum (strain Lp WJL ) buffers the adverse effects of chronic undernutrition on the growth of juvenile germ-free mice. Here, we report that Lp WJL sustains the postnatal growth of malnourished conventional animals and supports both insulin-like growth factor–1 (IGF-1) and insulin production and activity. We have identified cell walls isolated from Lp WJL , as well as muramyl dipeptide and mifamurtide, as sufficient cues to stimulate animal growth despite undernutrition. Further, we found that NOD2 is necessary in intestinal epithelial cells for Lp WJL -mediated IGF-1 production and for postnatal growth promotion in malnourished conventional animals. These findings indicate that, coupled with renutrition, bacteria cell walls or purified NOD2 ligands have the potential to alleviate stunting. |
| اللغة: | English |
| تدمد: | 0036-8075 1095-9203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e0b1c89e37b4a879efc92b583ff125 https://hal.science/hal-04014931 |
| رقم الأكسشن: | edsair.doi.dedup.....c1e0b1c89e37b4a879efc92b583ff125 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00368075 10959203 |
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