The Correlations of Plasma Liver-Type Fatty Acid-Binding Protein with Amyloid-β and Tau Levels in Patients with Alzheimer’s Disease
| العنوان: | The Correlations of Plasma Liver-Type Fatty Acid-Binding Protein with Amyloid-β and Tau Levels in Patients with Alzheimer’s Disease |
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| المؤلفون: | Yuan, Cheng, Jie-Ming, Jian, Chen-Yang, He, Jun-Rong, Ren, Man-Yu, Xu, Wang-Sheng, Jin, Cheng-Rong, Tan, Gui-Hua, Zeng, Ying-Ying, Shen, Dong-Wan, Chen, Hui-Yun, Li, Xu, Yi, Yuan, Zhang, Fan, Zeng, Yan-Jiang, Wang |
| المصدر: | Journal of Alzheimer's Disease. 88:375-383 |
| بيانات النشر: | IOS Press, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Amyloid beta-Peptides, General Neuroscience, tau Proteins, General Medicine, Fatty Acid-Binding Proteins, Peptide Fragments, Psychiatry and Mental health, Clinical Psychology, Cross-Sectional Studies, Liver, Alzheimer Disease, Humans, Geriatrics and Gerontology, Biomarkers |
| الوصف: | Background: The dysregulation of lipid metabolism plays an important role in the pathogenesis of Alzheimer’s disease (AD). Liver-type fatty acid-binding protein (L-FABP, also known as FABP1) is critical for fatty acid transport and may be involved in AD. Objective: To investigate whether the FABP1 level is altered in patients with AD, and its associations with levels of amyloid-β (Aβ) and tau in the plasma and cerebrospinal fluid (CSF). Methods: A cross-sectional study was conducted in a Chinese cohort consisting of 39 cognitively normal controls and 47 patients with AD. The levels of FABP1 in plasma, and Aβ and tau in CSF, were measured by enzyme-linked immunosorbent assay (ELISA). A single-molecule array (SIMOA) was used to detect plasma Aβ levels. Results: The level of plasma FABP1 was significantly elevated in the AD group (p = 0.0109). Further analysis showed a positive correlation of FABP1 with CSF total tau (t-tau) and phosphorylated tau (p-tau) levels. Besides, plasma FABP1/Aβ42 (AUC = 0.6794, p = 0.0071) and FABP1/t-tau (AUC = 0.7168, p = 0.0011) showed fair diagnostic efficacy for AD. When combined with other common AD biomarkers including plasma Aβ42, Aβ40, and t-tau, both FABP1/Aβ42 and FABP1/t-tau showed better diagnostic efficacy than using these biomarkers alone. Among all AUC analyses, the combination of plasma FABP1/t-tau and Aβ42 had the highest diagnostic value (AUC = 0.8075, p |
| تدمد: | 1875-8908 1387-2877 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e7cfe60e534c050f42728661d89d89 https://doi.org/10.3233/jad-220126 |
| رقم الأكسشن: | edsair.doi.dedup.....c1e7cfe60e534c050f42728661d89d89 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758908 13872877 |
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