Disposition and uric acid lowering effect of oxipurinol: comparison of different oxipurinol formulations and allopurinol in healthy individuals
| العنوان: | Disposition and uric acid lowering effect of oxipurinol: comparison of different oxipurinol formulations and allopurinol in healthy individuals |
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| المؤلفون: | Ingeborg Walter-Sack, J. X. de Vries, Andreas Voss, C. Kutschker, A. Ittensohn |
| المصدر: | European Journal of Clinical Pharmacology. 49:215-220 |
| بيانات النشر: | Springer Science and Business Media LLC, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Adult, Male, Allopurinol, Chemistry, Pharmaceutical, Cmax, Administration, Oral, Oxypurinol, Pharmacology, Dosage form, Gout Suppressants, chemistry.chemical_compound, Pharmacokinetics, Oral administration, medicine, Humans, Pharmacology (medical), Enzyme Inhibitors, Xanthine oxidase, Oxipurinol, Cross-Over Studies, General Medicine, Uric Acid, chemistry, Uric acid, medicine.drug |
| الوصف: | We have investigated the disposition and plasma uric acid lowering effect of oxipurinol in ten healthy individuals following oral administration of three different formulations of oxipurinol and of allopurinol in equimolar doses. The reduction of plasma uric acid was clearcut up to 48 h. As estimated from plasma AUC0-infinity, Cmax, tmax, tlag, and urinary drug excretion, a conventional rapid release preparation of oxipurinol sodium was clearly superior to oxipurinol as free acid and to enteric coated microtablets of oxipurinol sodium. Plasma oxipurinol concentrations following a single dose of the conventional formulation of oxipurinol sodium were approximately 25% lower than those observed after an equimolar dose (300 mg) of allopurinol, but mean Cmax reached the value reported to be necessary for 90% inhibition of xanthine oxidase. Since prolonged administration will result in accumulation of oxipurinol because of its slow elimination, this type of oxipurinol formulation can be expected to meet the therapeutic requirements for a drug to lower plasma uric acid. |
| تدمد: | 1432-1041 0031-6970 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fadf8ee08501a38e78609ac1bcd23f https://doi.org/10.1007/bf00192382 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....c1fadf8ee08501a38e78609ac1bcd23f |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321041 00316970 |
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