Silver Is Not Equal to Silver: Synthesis and Evaluation of Silver Nanoparticles with Low Biological Activity, and Their Incorporation into C12Alanine-Based Hydrogel
| العنوان: | Silver Is Not Equal to Silver: Synthesis and Evaluation of Silver Nanoparticles with Low Biological Activity, and Their Incorporation into C12Alanine-Based Hydrogel |
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| المؤلفون: | Konrad Kubiński, Kamila Górka, Monika Janeczko, Aleksandra Martyna, Mateusz Kwaśnik, Maciej Masłyk, Emil Zięba, Joanna Kowalczuk, Piotr Kuśtrowski, Mariusz Borkowski, Anna Boguszewska-Czubara, Agnieszka Klimeczek, Oleg M. Demchuk |
| المصدر: | Molecules Volume 28 Issue 3 Pages: 1194 |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | silver nanoparticles, TGA, Organic Chemistry, DLS, Pharmaceutical Science, biological activity, Z-potential, Analytical Chemistry, DSC, Chemistry (miscellaneous), Drug Discovery, SEM, drug delivery, XPS, Molecular Medicine, Physical and Theoretical Chemistry, hydrogels |
| الوصف: | A new type of silver nanoparticles (AgNPs) was prepared and comprehensively studied. Scanning electron microscopy (SEM) and dynamic light scattering (DLS) analyses indicated that 24 nm AgNPs with narrow size distribution were obtained while Z-potential confirms their good stability. The composites of the obtained AgNPs with nontoxic-nature-inspired hydrogel were formed upon cooling of the aqueous solution AgNPs and C12Ala. The thermal gravimetric analysis (TGA) and the differential scanning calorimetry (DSC) do not show significant shifts in the characteristic temperature peaks for pure and silver-enriched gels, which indicates that AgNPs do not strongly interact with C12Ala fibers, which was also confirmed by SEM. Both AgNPs alone and in the assembly with the gelator C12Ala were almost biologically passive against bacteria, fungus, cancer, and nontumor human cells, as well as zebra-fish embryos. These studies proved that the new inactive AgNPs-doped hydrogels have potential for the application in therapy as drug delivery media. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| DOI: | 10.3390/molecules28031194 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20708704a0780528bae9b35e7d90ed8 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c20708704a0780528bae9b35e7d90ed8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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| DOI: | 10.3390/molecules28031194 |