Engineering Swollen Cubosomes Using Cholesterol and Anionic Lipids
| العنوان: | Engineering Swollen Cubosomes Using Cholesterol and Anionic Lipids |
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| المؤلفون: | Nicholas J. Brooks, Robert V. Law, John M. Seddon, Hanna M. G. Barriga, Oscar Ces |
| المساهمون: | Engineering & Physical Science Research Council (EPSRC) |
| المصدر: | Langmuir. 35:16521-16527 |
| بيانات النشر: | American Chemical Society (ACS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Nanoparticle, Glycerophospholipids, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, Engineering, Electrochemistry, Molecule, General Materials Science, Lipid bilayer, Spectroscopy, chemistry.chemical_classification, Chemical Physics, Cholesterol, Biomolecule, Rational design, food and beverages, Surfaces and Interfaces, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Membrane, chemistry, Chemical engineering, Drug delivery, 0210 nano-technology |
| الوصف: | Dispersions of nonlamellar lipid membrane assemblies are gaining increasing interest for drug delivery and protein therapeutic application. A key bottleneck has been the lack of rational design rules for these systems linking different lipid species and conditions to defined lattice parameters and structures. We have developed robust methods to form cubosomes (nanoparticles with porous internal structures) with water channel diameters of up to 171 Å, which are over 4 times larger than archetypal cubosome structures. The water channel diameter can be tuned via the incorporation of cholesterol and the charged lipid DOPA, DOPG, or DOPS. We have found that large molecules can be incorporated into the porous cubosome structure and that these molecules can interact with the internal cubosome membrane. This offers huge potential for accessible encapsulation and protection of biomolecules and development of confined interfacial reaction environments. |
| تدمد: | 1520-5827 0743-7463 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27addeec0d102ce2348baba2955cc03 https://doi.org/10.1021/acs.langmuir.9b02336 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c27addeec0d102ce2348baba2955cc03 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205827 07437463 |
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