Serum Concentrations of Insulin, Ghrelin, Adiponectin, Leptin, Leptin Receptor and Lipocalin-2 in Children with Celiac Disease Who Do and Do Not Adhere to a Gluten-Free Diet
| العنوان: | Serum Concentrations of Insulin, Ghrelin, Adiponectin, Leptin, Leptin Receptor and Lipocalin-2 in Children with Celiac Disease Who Do and Do Not Adhere to a Gluten-Free Diet |
|---|---|
| المؤلفون: | Jerzy Socha, Anna Szaflarska-Popławska, Urszula Grzybowska-Chlebowczyk, Beata Oralewska, Anna Rybak, Aldona Wierzbicka-Rucińska, Barbara Iwańczak, Elżbieta Cytra-Jarocka, Roman Janas, Anna Stolarczyk, Wojciech Cichy, Rafał Śnitko, Piotr Socha, Grażyna Czaja-Bulsa |
| المصدر: | Gut and Liver |
| بيانات النشر: | The Editorial Office of Gut and Liver, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Leptin, Male, medicine.medical_specialty, Adolescent, Peptide Hormones, medicine.medical_treatment, Lipocalin, Pathogenesis, Diet, Gluten-Free, 03 medical and health sciences, 0302 clinical medicine, Lipocalin-2, Internal medicine, Humans, Insulin, Medicine, Child, Leptin receptor, Hepatology, Adiponectin, business.industry, digestive, oral, and skin physiology, Gastroenterology, nutritional and metabolic diseases, Ghrelin, digestive system diseases, Celiac Disease, Endocrinology, Child, Preschool, 030220 oncology & carcinogenesis, Immunology, Patient Compliance, Receptors, Leptin, Female, Original Article, 030211 gastroenterology & hepatology, Gluten free, business, hormones, hormone substitutes, and hormone antagonists |
| الوصف: | Background/Aims The roles of the many bioactive peptides in the pathogenesis of celiac disease remain unclear. To evaluate the serum concentrations of insulin, ghrelin, adiponectin, leptin, leptin receptor, and lipocalin-2 in children with celiac disease who do and do not adhere to a gluten-free diet (GFD, intermittent adherence). Methods Prepubertal, pubertal, and adolescent celiac children were included in this study (74 girls and 53 boys on a GFD and 80 girls and 40 boys off of a GFD). Results Insulin levels in prepubertal (9.01±4.43 μIU/mL), pubertal (10.3±3.62 μIU/mL), and adolescent (10.8±4.73 μIU/mL) girls were higher than those in boys (5.88±2.02, 8.81±2.88, and 8.81±2.26 μIU/mL, respectively) and were neither age-dependent nor influenced by a GFD. Prepubertal children off of a GFD exhibited higher ghrelin levels than prepubertal children on a GFD. Adiponectin levels were not age-, sex- nor GFD-dependent. Adherence to a GFD had no effect on the expression of leptin, leptin receptor, and lipocalin-2. Conclusions Adherence to a GFD had no influence on the adiponectin, leptin, leptin receptor, and lipocalin-2 concentrations in celiac children, but a GFD decreased highly elevated ghrelin levels in prepubertal children. Further studies are required to determine whether increased insulin concentrations in girls with celiac disease is suggestive of an increased risk for hyperinsulinemia. |
| تدمد: | 2005-1212 1976-2283 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2aee3466dee5bea8bb34f2e5c0d9d41 https://doi.org/10.5009/gnl15404 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c2aee3466dee5bea8bb34f2e5c0d9d41 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20051212 19762283 |
|---|