Mechanisms of the free fatty acid-induced increase in hepatic glucose production
| العنوان: | Mechanisms of the free fatty acid-induced increase in hepatic glucose production |
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| المؤلفون: | Adria Giacca, I. George Fantus, Tony K.T. Lam, Gary F. Lewis, André C. Carpentier, Gérald van de Werve |
| المصدر: | American Journal of Physiology-Endocrinology and Metabolism. 284:E863-E873 |
| بيانات النشر: | American Physiological Society, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | medicine.medical_specialty, Time Factors, Physiology, Endocrinology, Diabetes and Metabolism, Fatty Acids, Nonesterified, Biology, Carbohydrate metabolism, Insulin resistance, Physiology (medical), Internal medicine, medicine, Hyperinsulinemia, Animals, Homeostasis, Humans, Insulin, chemistry.chemical_classification, Gluconeogenesis, Type 2 Diabetes Mellitus, Fatty acid, Lipid metabolism, Metabolism, Lipid Metabolism, medicine.disease, Endocrinology, Liver, chemistry |
| الوصف: | The associations between obesity, insulin resistance, and type 2 diabetes mellitus are well documented. Free fatty acids (FFA), which are often elevated in obesity, have been implicated as an important link in these associations. Contrary to muscle glucose metabolism, the effects of FFA on hepatic glucose metabolism and the associated mechanisms have not been extensively investigated. It is still controversial whether FFA have substantial effects on hepatic glucose production, and the mechanisms responsible for these putative effects remain unknown. We review recent progress in this area and try to clarify controversial issues regarding the mechanisms responsible for the FFA-induced increase in hepatic glucose production in the postabsorptive state and during hyperinsulinemia. |
| تدمد: | 1522-1555 0193-1849 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c903ffd1a6c495403f87a18e5044a5 https://doi.org/10.1152/ajpendo.00033.2003 |
| رقم الأكسشن: | edsair.doi.dedup.....c2c903ffd1a6c495403f87a18e5044a5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221555 01931849 |
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