Effects of the Aqueous Extract of Eremomastax speciosa (Acanthaceae) on Sexual Behavior in Normal Male Rats
| العنوان: | Effects of the Aqueous Extract of Eremomastax speciosa (Acanthaceae) on Sexual Behavior in Normal Male Rats |
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| المؤلفون: | F. Longo, Paul V. Tan, Z. E. Nkwengoua, A. P. Amang, B. Nchegang, Christophe Mezui |
| المصدر: | BioMed Research International BioMed Research International, Vol 2016 (2016) |
| بيانات النشر: | Hindawi Publishing Corporation, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Eremomastax speciosa, Male, medicine.medical_specialty, Article Subject, Ejaculation, lcsh:Medicine, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Sexual Behavior, Animal, 0302 clinical medicine, Internal medicine, Acanthaceae, medicine, Haloperidol, Animals, Testosterone, Aqueous extract, General Immunology and Microbiology, biology, business.industry, Plant Extracts, Dopaminergic, lcsh:R, General Medicine, biology.organism_classification, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Atropine, Endocrinology, Sexual behavior, business, 030217 neurology & neurosurgery, medicine.drug, Research Article |
| الوصف: | Objective. We studied prosexual effects ofEremomastax speciosaaqueous extract in male adult rats.Materials and Methods. 100 and 500 mg/kg of extract were administered orally (days 0, 1, 4, 7, 14, and 28 (posttreatment)). The sexual behavior of rats receiving a single dose (500 mg/kg) was also evaluated after pretreatment with Lω-NAME (10 mg/kg), haloperidol (1 mg/kg), or atropine (5 mg/kg). Controls received distilled water or testosterone enanthate (20 mg/kg/day/3 days(s.c.)before the test).Results. The extract (days 1–14) had no significant effect on mount, intromission, and ejaculation frequencies but on day 28 (14 days after treatment), it increased frequency of mounts and intromissions at 500 mg/kg. Mount, intromission, and ejaculation latencies reduced and postejaculatory intervals decreased but the effect did not persist 2 weeks after treatment. Extract prosex effects were greatly reduced by atropine and completely abolished by haloperidol, while Lω-NAME increased mount latency and potentiated extract effect on intromission and ejaculation latencies.Conclusion. In summary,E. speciosaextract can have positive effects on male sexual motivation and performance when administered for two weeks at the dose of 500 mg/kg. The effects (dopaminergic and/or cholinergic dependent) tend to appear during the posttreatment period. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2314-6141 2314-6133 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fbe82e3218d421a2739b4239b3a28b http://europepmc.org/articles/PMC4971301 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c2fbe82e3218d421a2739b4239b3a28b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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