IFN-gamma stimulates IgG2 production from bovine B cells costimulated with anti-mu and mitogen

التفاصيل البيبلوغرافية
العنوان: IFN-gamma stimulates IgG2 production from bovine B cells costimulated with anti-mu and mitogen
المؤلفون: D M Estes, Allen Gk, Closser Nm
المصدر: Cellular immunology. 154(1)
سنة النشر: 1994
مصطلحات موضوعية: Interleukin 2, Male, medicine.medical_specialty, medicine.medical_treatment, T cell, Immunology, Molecular Sequence Data, Immunoglobulin E, Lymphocyte Activation, Interferon-gamma, Internal medicine, medicine, Animals, Interferon gamma, RNA, Messenger, B cell, B-Lymphocytes, biology, Base Sequence, Isotype, Molecular biology, Antibodies, Anti-Idiotypic, medicine.anatomical_structure, Endocrinology, Cytokine, Immunoglobulin M, Immunoglobulin G, biology.protein, Interleukin-2, Cattle, Antibody, Mitogens, medicine.drug
الوصف: The effect of interferon-gamma (IFN-gamma) antibody production by anti-mu- or pokeweed mitogen-stimulated bovine B cells was studied. IFN-gamma induced IgG2 secretion in isolated bulk B cell populations and in B cells sorted for IgM expression. IgM production was suppressed by the presence of IFN-gamma alone but this effect was antagonized by interleukin 2 (IL2). The effects of IFN-gamma on secreted levels of IgM, IgG1, and IgG2 correlated with the frequencies of cells expressing transcripts of the respective isotypes when stimulated with IFN-gamma-containing T cell supernatants. These results indicate that IFN-gamma plays a key role in IgG2 production in the bovine by directly affecting suitably stimulated B cells. The ability of IL2 to synergize with IFN-gamma to augment both the IgM and IgG2 responses implicates a TH1-like subset in regulation of this isotype.
تدمد: 0008-8749
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39717ef9506b7c983fefbc60e2f8f25
https://pubmed.ncbi.nlm.nih.gov/8131203
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....c39717ef9506b7c983fefbc60e2f8f25
قاعدة البيانات: OpenAIRE