Compromised autophagy by MIR30B benefits the intracellular survival of Helicobacter pylori
| العنوان: | Compromised autophagy by MIR30B benefits the intracellular survival of Helicobacter pylori |
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| المؤلفون: | Yao-ren Fang, Jiang Gu, Li Chen, Xuejun Jiang, Bin Tang, Jin-yu Zhang, Quanming Zou, Na Li, Hai-guang Wang, Qian Li, Bin Xiao, Qing-Hua Xie, Xuhu Mao, Yuan-Yuan Zhuang, Bo Yu |
| المصدر: | Autophagy |
| بيانات النشر: | Landes Bioscience, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | autophagy, ATG12, Molecular Sequence Data, Intracellular Space, Down-Regulation, Biology, Cell Line, Helicobacter Infections, Immune system, Downregulation and upregulation, Cell Line, Tumor, microRNA, Humans, Molecular Biology, Microbial Viability, Helicobacter pylori, Base Sequence, Autophagy, Membrane Proteins, Cell Biology, BECN1, biology.organism_classification, bacterial infections and mycoses, Basic Research Paper, Up-Regulation, MicroRNAs, Immunology, Small Ubiquitin-Related Modifier Proteins, Beclin-1, Apoptosis Regulatory Proteins, Intracellular, Autophagy-Related Protein 12, MIR30B |
| الوصف: | Helicobacter pylori evade immune responses and achieve persistent colonization in the stomach. However, the mechanism by which H. pylori infections persist is not clear. In this study, we showed that MIR30B is upregulated during H. pylori infection of an AGS cell line and human gastric tissues. Upregulation of MIR30B benefited bacterial replication by compromising the process of autophagy during the H. pylori infection. As a potential mechanistic explanation for this observation, we demonstrate that MIR30B directly targets ATG12 and BECN1, which are important proteins involved in autophagy. These results suggest that compromise of autophagy by MIR30B allows intracellular H. pylori to evade autophagic clearance, thereby contributing to the persistence of H. pylori infections. |
| اللغة: | English |
| تدمد: | 1554-8635 1554-8627 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a9f2756d1f6e5641f501a8f4125f9a http://europepmc.org/articles/PMC3429542 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c3a9f2756d1f6e5641f501a8f4125f9a |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15548635 15548627 |
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