Neutrophil function, nitric oxide, and blood oxidative stress in Parkinson's disease
| العنوان: | Neutrophil function, nitric oxide, and blood oxidative stress in Parkinson's disease |
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| المؤلفون: | Natalia A. Riobo, Manuel Fernandez Pardal, Marisa G. Repetto, Emilia Gatto, Susana Llesuy, Juan José Poderoso, Claudia Reides, Maria Cecilia Carreras, Griselda A. Pargament |
| المصدر: | Movement Disorders. 11:261-267 |
| بيانات النشر: | Wiley, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Erythrocytes, Parkinson's disease, Free Radicals, Neutrophils, Neutrophile, Stimulation, Nitric Oxide, medicine.disease_cause, Nitric oxide, Antiparkinson Agents, Levodopa, Pathogenesis, chemistry.chemical_compound, Internal medicine, Humans, Medicine, chemistry.chemical_classification, Reactive oxygen species, biology, Superoxide Dismutase, business.industry, Carbidopa, Parkinson Disease, Hydrogen Peroxide, Middle Aged, Catalase, medicine.disease, Oxidative Stress, Endocrinology, Neurology, chemistry, Luminescent Measurements, Immunology, biology.protein, Drug Therapy, Combination, Female, Neurology (clinical), Reactive Oxygen Species, business, Oxidative stress |
| الوصف: | We studied nitrogen radical nitric oxide (.NO) release and reactive oxygen species (ROS) production by isolated neutrophils after phorbol myristate acetate (PMA) stimulation in 12 newly diagnosed and nine treated Parkinson's disease (PD) patients and 10 age-matched healthy controls. Neutrophils of both groups of PD patients had an elevated PMA-activated release of .NO [61 and 57%, respectively, higher than that of controls (p < 0.05)]. In contrast, H2O2 release was only significantly increased by 56% in chronically treated patients. In agreement, the maximum rate of luminol-dependent chemiluminescence, which partly represents O2- H2O2- .NO interactions, was increased only in the treated group. When other blood markers of oxidative stress were compared, only erythrocyte catalase activity was decreased in both PD patient series by 33 and 39%, respectively (p < 0.05), whereas plasma antioxidant capacity and erythrocyte superoxide dismutase activity levels were decreased only in treated PD patients. This study suggests that neutrophils express a primary alteration of .NO release in PD patients, whereas H2O2 and oxidative-stress parameters are more probably related to the evolution of PD or to effects of treatment with L-dopa. |
| تدمد: | 1531-8257 0885-3185 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f2a7cec460cda960728478a31eb7cd https://doi.org/10.1002/mds.870110308 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....c3f2a7cec460cda960728478a31eb7cd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15318257 08853185 |
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