A randomized trial of basiliximab with three different patterns of cyclosporin A initiation in renal transplant from expanded criteria donors and at high risk of delayed graft function
| العنوان: | A randomized trial of basiliximab with three different patterns of cyclosporin A initiation in renal transplant from expanded criteria donors and at high risk of delayed graft function |
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| المؤلفون: | Amado, Andrés, Roberto, Marcén, Francisco, Valdés, Jaime Sánchez, Plumed, Ricard, Solà, Pedro, Errasti, Ricardo, Lauzurica, Luis, Pallardó, Jesús, Bustamante, Juan José, Amenábar, Juan José, Plaza, Ernesto, Gómez, Josep Maria, Grinyó, Manuel, Rengel, Josep Maria, Puig, Aurelio, Sanz, Concepción, Asensio, Inés, Andrés, A, Osuna |
| المصدر: | Clinical Transplantation. 23:23-32 |
| بيانات النشر: | Wiley, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Graft Rejection, Male, medicine.medical_specialty, Basiliximab, Recombinant Fusion Proteins, Urology, Delayed Graft Function, Renal function, Kidney Function Tests, Risk Factors, Cyclosporin a, medicine, Humans, Prospective Studies, Survival rate, Kidney transplantation, Transplantation, business.industry, Graft Survival, Antibodies, Monoclonal, Middle Aged, Mycophenolic Acid, Ciclosporin, medicine.disease, Kidney Transplantation, Surgery, Survival Rate, Calcineurin, Treatment Outcome, Cyclosporine, Drug Therapy, Combination, Female, business, Immunosuppressive Agents, medicine.drug |
| الوصف: | This study assays therapy with basiliximab and different patterns of cyclosporin A (CsA) initiation in renal transplant (RT) recipients from expanded criteria donors (ECD) and at high risk of delayed graft function (DGF). A multicentre six-month open-label randomized trial with three parallel groups treated with basiliximab plus steroids, mycophenolate mofetil and different patterns of CsA initiation: early within 24 h post-RT at 3 mg/kg/d (Group 1; n = 38), and at 5 mg/kg/d (Group 2; n = 40), or delayed after 7-10 d at 5 mg/kg/d (Group 3; n = 36). There were no differences among groups in six months GFR (43.1 +/- 12, 48.0 +/- 14 and 47.2 +/- 17 mL/min, respectively), DGF (Group 1: 31%, Group 2: 37%, Group 3: 42%), nor biopsy-proven acute rejection, although clinically treated and biopsy-proven acute rejection was significantly higher in Group 3 (25%) vs. Group 1 (5.3%, p < 0.05). At six months no differences were observed in death-censored graft survival or patient survival. Induction therapy with basiliximab and three CsA-ME initiation patterns in RT recipients from ECD and at high risk of DGF presented good renal function and graft survival at six months. Late onset group did not achieve improvement in DGF rate and showed a higher incidence of clinically treated and biopsy-proven acute rejection. |
| تدمد: | 1399-0012 0902-0063 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c420502ff1f3542e54f3c4845c86491a https://doi.org/10.1111/j.1399-0012.2008.00891.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....c420502ff1f3542e54f3c4845c86491a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13990012 09020063 |
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