Transcriptomic Sequencing Reveals a Set of Unique Genes Activated by Butyrate-Induced Histone Modification
| العنوان: | Transcriptomic Sequencing Reveals a Set of Unique Genes Activated by Butyrate-Induced Histone Modification |
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| المؤلفون: | Sitao Wu, Weizhong Li, Ransom L. Baldwin Vi, Le Ann Blomberg, Robert W. Li, Congjun Li |
| المصدر: | Gene Regulation and Systems Biology, Vol 10 (2016) Gene Regulation and Systems Biology Gene Regulation and Systems Biology, Vol 2016, Iss 10, Pp 1-8 (2016) |
| بيانات النشر: | SAGE Publishing, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.drug_class, Butyrate, bovine cells, Bioinformatics, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Genetics, Medicine, histone modification, Epigenetics, Molecular Biology, Gene, lcsh:QH301-705.5, Ecology, Evolution, Behavior and Systematics, Original Research, Epigenomics, Regulation of gene expression, biology, business.industry, Histone deacetylase inhibitor, transcriptomic, butyrate, Computer Science Applications, Cell biology, 030104 developmental biology, Histone, lcsh:Biology (General), biology.protein, gene regulation, business, 030217 neurology & neurosurgery |
| الوصف: | Butyrate is a nutritional element with strong epigenetic regulatory activity as a histone deacetylase inhibitor. Based on the analysis of differentially expressed genes in the bovine epithelial cells using RNA sequencing technology, a set of unique genes that are activated only after butyrate treatment were revealed. A complementary bioinformatics analysis of the functional category, pathway, and integrated network, using Ingenuity Pathways Analysis, indicated that these genes activated by butyrate treatment are related to major cellular functions, including cell morphological changes, cell cycle arrest, and apoptosis. Our results offered insight into the butyrate-induced transcriptomic changes and will accelerate our discerning of the molecular fundamentals of epigenomic regulation. |
| اللغة: | English |
| تدمد: | 1177-6250 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46b6c96397363ca2d5bd6bae76bdd8d https://doaj.org/article/204ab20c95334a079b36c12f48695a44 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c46b6c96397363ca2d5bd6bae76bdd8d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11776250 |
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