SARS -CoV-2 T-cell immunity to variants of concern following vaccination
| العنوان: | SARS -CoV-2 T-cell immunity to variants of concern following vaccination |
|---|---|
| المؤلفون: | Gabrielle Brini, Jennifer Y. Yam, Kathleen Gallagher, Katelin Katsis, Rebecca C. Larson, Trisha R. Berger, Mark B. Leick, Marcela V. Maus, Korneel Grauwet |
| المصدر: | bioRxiv article-version (status) pre article-version (number) 1 |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Vaccination, Immune system, Immunity, Viral entry, viruses, biology.protein, Wild type, Virulence, Biology, Antibody, Virology, Neutralization, Article |
| الوصف: | SUMMARYRecently, two mRNA vaccines to severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) have become available, but there is also an emergence of SARS-CoV-2 variants with increased transmissibility and virulence1–6. A major concern is whether the available vaccines will be equally effective against these variants. The vaccines are designed to induce an immune response against the SARS-CoV-2 spike protein7, 8, which is required for viral entry to host cells9. Immunity to SARS-CoV-2 is often evaluated by antibody production, while less is known about the T-cell response. Here we developed, characterized, and implemented two standardized, functional assays to measure T-cell immunity to SARS-CoV-2 in uninfected, convalescent, and vaccinated individuals. We found that vaccinated individuals had robust T-cell responses to the wild type spike and nucleocapsid proteins, even more so than convalescent patients. We also found detectable but diminished T-cell responses to spike variants (B.1.1.7, B.1.351, and B.1.1.248) among vaccinated but otherwise healthy donors. Since decreases in antibody neutralization have also been observed with some variants10–12, investigation into the T-cell response to these variants as an alternative means of viral control is imperative. Standardized measurements of T-cell responses to SARS-CoV-2 are feasible and can be easily adjusted to determine changes in response to variants. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4dc9339d076ffcff528cd06afa687bc https://pubmed.ncbi.nlm.nih.gov/33972942 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c4dc9339d076ffcff528cd06afa687bc |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |