Translocation detection in lymphoma diagnosis by split-signal FISH: a standardised approach
| العنوان: | Translocation detection in lymphoma diagnosis by split-signal FISH: a standardised approach |
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| المؤلفون: | David Y. Mason, Margaret Jones, Mette Christiansen, Jacques J.M. van Dongen, Stephen Hamilton Dutoit, Tim Svenstrup Poulsen, Maryse Baia, Christiane Copie Bergman, Steen Hauge Matthiesen, Evi Pouliou, José Cabeçadas, Dimitra Anagnostou, Juan F. García, Mateus Crespo, Anja Mottok, J. Han van Krieken, Anke van Rijk, Juan C. Cigudosa, Lorenzo Leoncini, Martin-Leo Hansmann, Mario Cocco |
| المساهمون: | Virology, Surgery, Immunology |
| المصدر: | Journal of Hematopathology, 1, 119-126. Springer-Verlag Aarhus University Journal of Hematopathology van Rijk, A, Mason, D, Jones, M, Cabeçadas, J, Crespo, M, Cigudosa, JC, Garcia, JF, Leoncini, L, Cocco, M, Hansmann, ML, Mottok, A, Bergman, CC, Gaulard, P, Anagnostou, D, Pouliou, E, Hamilton-Dutoit, S J, Christiansen, MH, Poulsen, TS, Matthiesen, SH, van Dongen, J & van Krieken, JH 2008, ' Translocation detection in lymphoma diagnosis by split-signal FISH: a standardised approach. ', Journal of Hematopathology (Online), vol. 1, pp. 119-26 . |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Protocol (science), Histology, Lymphoma, Chemistry(all), business.industry, Lymphoma diagnosis, Energy Engineering and Power Technology, Hematology, Computational biology, Physics and Astronomy(all), Classification, Bioinformatics, Chromosomal aberration, Pollution, World health, Pathology and Forensic Medicine, Split-signal FISH, Fuel Technology, In situ hybridisation, Validation, Chemical Engineering(all), Medicine, Fish |
| الوصف: | Lymphomas originating from the lymphatic system comprise about 30 entities classified according to the World Health Organization (WHO). The histopathological diagnosis is generally considered difficult and prone to mistakes. Since non-random chromosomal translocations are specifically involved in different lymphoma entities, their detection will be increasingly important. Hence, a split-signal fluorescence in situ hybridisation (FISH) procedure would be helpful in discriminating the most difficult classifications. The Euro-FISH programme, a concerted action of nine European laboratories, has validated a robust, standardised protocol to improve the diagnostic approach on lymphoma entities. Therefore, 16 fluorescent probes and 10 WHO entities, supplemented with reactive cases, were selected. The results of the Euro-FISH programme show that all probes were correctly cytogenetically located, that the standardised protocol is robust, resulting in reliable results in approximately 90% of cases, and that the procedure could be implemented in every laboratory, bringing the relatively easy interpretation of split-signal probes within the reach of many pathology laboratories. |
| وصف الملف: | application/pdf |
| تدمد: | 1865-5785 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c568f90fd4838f03de0886c355412294 https://doi.org/10.1007/s12308-008-0017-5 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c568f90fd4838f03de0886c355412294 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18655785 |
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