Consequences of in utero exposure to Zika virus in offspring of AG129 mice
| العنوان: | Consequences of in utero exposure to Zika virus in offspring of AG129 mice |
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| المؤلفون: | Justin G. Julander, Pranav Dinesh Mathur, Michael Bertolio, Donal G. Sinex, Venkatraman Siddharthan, Hong Wang, Arnaud J. Van Wettere, Katherine Zukor, Elizabeth Preston, Albert H. Park, John D. Morrey |
| المساهمون: | Nature |
| المصدر: | Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018) Scientific Reports Animal, Dairy, and Veterinary Science Faculty Publications |
| بيانات النشر: | Nature Publishing Group, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Offspring, Physiology, Intrauterine growth restriction, lcsh:Medicine, Dairy Science, Virus, Article, Zika virus, 03 medical and health sciences, Mice, Pregnancy, Positron Emission Tomography Computed Tomography, medicine, Animals, Pregnancy Complications, Infectious, lcsh:Science, reproductive and urinary physiology, Mice, Knockout, Fetus, Multidisciplinary, Fetal Growth Retardation, Microscopy, Confocal, biology, Zika Virus Infection, Mortality rate, viral transmission, lcsh:R, pathogens, Zika Virus, biology.organism_classification, medicine.disease, Immunohistochemistry, 3. Good health, Disease Models, Animal, 030104 developmental biology, In utero, Animal Sciences, Gestation, RNA, Viral, Female, lcsh:Q |
| الوصف: | Zika virus (ZIKV) can cause various diseases in offspring after congenital infection. The purpose of this study was to identify disease phenotypes in pups exposed to ZIKV in utero. Female interferon-α/β, -γ receptor knockout mice (AG129) were infected intraperitoneally with ZIKV 7.5 days’ post coitus (dpc). Viral RNA, antigen and infectious virus were detected in some, but not all, maternal and fetal tissues at various times during gestation. Fetuses of infected dams had significant intrauterine growth restriction (IUGR), which was more pronounced as females neared parturition. Pups born to infected dams were significantly smaller and had significantly shortened skull lengths, as determined by measurement with a caliper and by micro-CT analysis, as compared with age-matched controls. Growth rates of exposed pups after birth, however, was similar to sham-exposed offspring. Viral RNA was detected in pups of infected dams after birth. A lower survival rate was observed in neonates exposed to ZIKV in utero. A mortality rate of over 50%, attributed to consequences of ZIKV infection, occurred after birth in pups born to infected dams. A transient hearing loss was observed in some animals exposed to virus in utero. No motor deficits or cognitive deficits were detected using running wheel or viral paresis scoring assays. Abnormalities in offspring included smaller size, shorter skull length and increased neonatal mortality, while the only functional deficit we could detect was a low incidence of transient hearing loss. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ea39460d892a6ef85f51dea04fc6fd http://link.springer.com/article/10.1038/s41598-018-27611-x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c5ea39460d892a6ef85f51dea04fc6fd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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