Porcine Epidemic Diarrhea Virus Induces Autophagy to Benefit Its Replication
| العنوان: | Porcine Epidemic Diarrhea Virus Induces Autophagy to Benefit Its Replication |
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| المؤلفون: | Qigai He, Guokai Yan, Shengxian Fan, Zhonghua Li, Yinxing Zhu, Xin Tan, Meizhou Wu, Xiaozhen Guo, Xiaoqian Zhang, Bingzhou Zhang, Mengjia Zhang, Atta Muhammad Memon, Wei Zeng, Xugang Ku, Hengke Guo |
| المصدر: | Viruses, Vol 9, Iss 3, p 53 (2017) Viruses; Volume 9; Issue 3; Pages: 53 Viruses |
| بيانات النشر: | MDPI AG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Blotting, Western, lcsh:QR1-502, Virus Replication, Virus, Article, lcsh:Microbiology, Proinflammatory cytokine, 03 medical and health sciences, Microscopy, Electron, Transmission, autophagy machinery, inflammatory responses, RNA interference, Virology, Chlorocebus aethiops, Autophagy, Animals, Vero Cells, PEDV replication, Microscopy, Confocal, biology, Porcine epidemic diarrhea virus, apoptosis, biology.organism_classification, 030104 developmental biology, Infectious Diseases, Viral replication, Apoptosis, Host-Pathogen Interactions, Vero cell |
| الوصف: | The new porcine epidemic diarrhea (PED) has caused devastating economic losses to the swine industry worldwide. Despite extensive research on the relationship between autophagy and virus infection, the concrete role of autophagy in porcine epidemic diarrhea virus (PEDV) infection has not been reported. In this study, autophagy was demonstrated to be triggered by the effective replication of PEDV through transmission electron microscopy, confocal microscopy, and Western blot analysis. Moreover, autophagy was confirmed to benefit PEDV replication by using autophagy regulators and RNA interference. Furthermore, autophagy might be associated with the expression of inflammatory cytokines and have a positive feedback loop with the NF-κB signaling pathway during PEDV infection. This work is the first attempt to explore the complex interplay between autophagy and PEDV infection. Our findings might accelerate our understanding of the pathogenesis of PEDV infection and provide new insights into the development of effective therapeutic strategies. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1999-4915 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c615b75927aae8187a56d02ca4372396 http://www.mdpi.com/1999-4915/9/3/53 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c615b75927aae8187a56d02ca4372396 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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