Circulating adrenomedullin and B-type natriuretic peptide do not predict blood pressure fluctuations during pheochromocytoma resection
| العنوان: | Circulating adrenomedullin and B-type natriuretic peptide do not predict blood pressure fluctuations during pheochromocytoma resection |
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| المؤلفون: | Eleonora P M Corssmit, Ineke J. Riphagen, Elisabeth M. W. Eekhoff, Henri J L M Timmers, Thera P. Links, Michiel N. Kerstens, Anouk N A van der Horst-Schrivers, Anneke C. Muller Kobold, Annika M A Berends, Edward Buitenwerf, Jacques W.M. Lenders, Richard A Feelders, Coen A. Stegeman, Schelto Kruijff, Ronald Groote Veldman, Harm R. Haak |
| المساهمون: | Internal Medicine, Internal medicine, AMS - Musculoskeletal Health, AMS - Tissue Function & Regeneration, Amsterdam Gastroenterology Endocrinology Metabolism, APH - Quality of Care, ACS - Heart failure & arrhythmias, Anesthesiology, Surgery, APH - Global Health, ACS - Microcirculation, RS: CAPHRI - R1 - Ageing and Long-Term Care, Interne Geneeskunde, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Translational Immunology Groningen (TRIGR), Groningen Kidney Center (GKC) |
| المصدر: | European Journal of Endocrinology, 185(4), 507-514. Bioscientifica Ltd European Journal of Endocrinology, 185, 4, pp. 507-514 European Journal of Endocrinology, 185, 507-514 European Journal of Endocrinology, 185(4), 507-514. BIOSCIENTIFICA LTD European Journal of Endocrinology, 185(4), 507-514. BioScientifica Ltd. Berends, A M A, Buitenwerf, E, Riphagen, I J, Lenders, J W M, Timmers, H J L M, Kruijff, S, Links, T P, van der Horst-Schrivers, A N A, Stegeman, C A, Eekhoff, E M W, Feelders, R A, Corssmit, E P M, Veldman, R G, Haak, H R, Kobold, A C M & Kerstens, M N 2021, ' Circulating adrenomedullin and B-type natriuretic peptide do not predict blood pressure fluctuations during pheochromocytoma resection: A cross-sectional study ', European Journal of Endocrinology, vol. 185, no. 4, pp. 507-514 . https://doi.org/10.1530/EJE-20-1452 |
| بيانات النشر: | BIOSCIENTIFICA LTD, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Adrenal Gland Neoplasms, Blood Pressure, Adrenomedullin, Endocrinology, Natriuretic Peptide, Brain, Natriuretic peptide, Intraoperative Complications, PLASMA, Cumulative dose, INFUSION, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], General Medicine, Middle Aged, MIDREGIONAL PROADRENOMEDULLIN, Prognosis, PROGNOSTIC VALUE, Treatment Outcome, Cardiovascular Diseases, HEART, Female, Adult, Adrenergic Antagonists, medicine.medical_specialty, medicine.drug_class, Urology, Pheochromocytoma, Risk Assessment, PATIENT, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, Internal medicine, medicine, Humans, Sympathetic Paraganglioma, Aged, Heart Failure, business.industry, Perioperative, medicine.disease, CARDIAC EVENTS, Cross-Sectional Studies, Blood pressure, business, NONCARDIAC SURGERY, Biomarkers, Follow-Up Studies |
| الوصف: | Background Despite adequate presurgical management, blood pressure fluctuations are common during resection of pheochromocytoma or sympathetic paraganglioma (PPGL). To a large extent, the variability in blood pressure control during PPGL resection remains unexplained. Adrenomedullin and B-type natriuretic peptide, measured as MR-proADM and NT-proBNP, respectively, are circulating biomarkers of cardiovascular dysfunction. We investigated whether plasma levels of MR-proADM and NT-proBNP are associated with blood pressure fluctuations during PPGL resection. Methods Study subjects participated in PRESCRIPT, a randomized controlled trial in patients undergoing PPGL resection. MR-proADM and NT-proBNP were determined in a single plasma sample drawn before surgery. Multivariable linear and logistic regression analyses were used to explore associations between these biomarkers and blood pressure fluctuations, use of vasoconstrictive agents during surgery as well as the occurrence of perioperative cardiovascular events. Results A total of 126 PPGL patients were included. Median plasma concentrations of MR-proADM and NT-proBNP were 0.51 (0.41–0.63) nmol/L and 68.7 (27.9–150.4) ng/L, respectively. Neither MR-proADM nor NT-proBNP were associated with blood pressure fluctuations. There was a positive correlation between MR-proADM concentration and the cumulative dose of vasoconstrictive agents (03B2 0.44, P =0.001). Both MR-proADM and NT-proBNP were significantly associated with perioperative cardiovascular events (OR: 5.46, P =0.013 and OR: 1.54, P =0.017, respectively). Conclusions plasma MR-proADM or NT-proBNP should not be considered as biomarkers for the presurgical risk assessment of blood pressure fluctuations during PPGL resection. Future studies are needed to explore the potential influence of these biomarkers on the intraoperative requirement of vasoconstrictive agents and the perioperative cardiovascular risk. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0804-4643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6271c6b1d7a232004fd476466bf8ea1 https://hdl.handle.net/1887/3237875 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c6271c6b1d7a232004fd476466bf8ea1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08044643 |
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