Flipping the Switch from G1 to S Phase with E3 Ubiquitin Ligases
| العنوان: | Flipping the Switch from G1 to S Phase with E3 Ubiquitin Ligases |
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| المؤلفون: | Lindsay F. Rizzardi, Jeanette Gowen Cook |
| المصدر: | Genes & Cancer. 3:634-648 |
| بيانات النشر: | SAGE Publications, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | DNA re-replication, Genetics, Cancer Research, digestive, oral, and skin physiology, Eukaryotic DNA replication, S-phase-promoting factor, Biology, Pre-replication complex, Cell biology, Control of chromosome duplication, Origin recognition complex, Monographs, Biochemical switches in the cell cycle, S phase |
| الوصف: | The cell cycle ensures genome maintenance by coordinating the processes of DNA replication and chromosome segregation. Of particular importance is the irreversible transition from the G1 phase of the cell cycle to S phase. This transition marks the switch from preparing chromosomes for replication ("origin licensing") to active DNA synthesis ("origin firing"). Ubiquitin-mediated proteolysis is essential for restricting DNA replication to only once per cell cycle and is the major mechanism regulating the G1 to S phase transition. Although some changes in protein levels are attributable to regulated mRNA abundance, protein degradation elicits very rapid changes in protein abundance and is critical for the sharp and irreversible transition from one cell cycle stage to the next. Not surprisingly, regulation of the G1-to-S phase transition is perturbed in most cancer cells, and deregulation of key molecular events in G1 and S phase drives not only cell proliferation but also genome instability. In this review we focus on the mechanisms by which E3 ubiquitin ligases control the irreversible transition from G1 to S phase in mammalian cells. |
| تدمد: | 1947-6027 1947-6019 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67664316486f42ca547f337776fba33 https://doi.org/10.1177/1947601912473307 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c67664316486f42ca547f337776fba33 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19476027 19476019 |
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