Entorhinal-retrosplenial circuits for allocentric-egocentric transformation of boundary coding
| العنوان: | Entorhinal-retrosplenial circuits for allocentric-egocentric transformation of boundary coding |
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| المؤلفون: | van Wijngaarden, Joeri BG, Babl, Susanne S, Ito, Hiroshi T |
| المصدر: | eLife eLife, Vol 9 (2020) |
| بيانات النشر: | eLife Sciences Publications, Ltd, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, retrosplenial cortex, QH301-705.5, Computer science, Science, Normal Distribution, Optogenetics, Gyrus Cinguli, Spatial memory, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Retrosplenial cortex, Border cells, Animals, Rats, Long-Evans, Prospective Studies, Chromatin structure remodeling (RSC) complex, Biology (General), Neurons, Landmark, Behavior, Animal, entorhinal cortex, General Immunology and Microbiology, biology, egocentric-allocentric transformation, General Neuroscience, General Medicine, Entorhinal cortex, Rats, 030104 developmental biology, Microscopy, Fluorescence, border cell, Space Perception, biology.protein, Rat, Medicine, Monte Carlo Method, Neuroscience, 030217 neurology & neurosurgery, Research Article, Spatial Navigation, Coding (social sciences) |
| الوصف: | Spatial navigation requires landmark coding from two perspectives, relying on viewpoint-invariant and self-referenced representations. The brain encodes information within each reference frame but their interactions and functional dependency remains unclear. Here we investigate the relationship between neurons in the rat's retrosplenial cortex (RSC) and entorhinal cortex (MEC) that increase firing near boundaries of space. Border cells in RSC specifically encode walls, but not objects, and are sensitive to the animal’s direction to nearby borders. These egocentric representations are generated independent of visual or whisker sensation but are affected by inputs from MEC that contains allocentric spatial cells. Pharmaco- and optogenetic inhibition of MEC led to a disruption of border coding in RSC, but not vice versa, indicating allocentric-to-egocentric transformation. Finally, RSC border cells fire prospective to the animal’s next motion, unlike those in MEC, revealing the MEC-RSC pathway as an extended border coding circuit that implements coordinate transformation to guide navigation behavior. |
| وصف الملف: | application/pdf |
| تدمد: | 2050-084X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c49d7eeae47eb2faba623b3e1a4ceb https://doi.org/10.7554/elife.59816 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c6c49d7eeae47eb2faba623b3e1a4ceb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2050084X |
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