Androprostamines A and B, the new anti-prostate cancer agents produced by Streptomyces sp. MK932-CF8
| العنوان: | Androprostamines A and B, the new anti-prostate cancer agents produced by Streptomyces sp. MK932-CF8 |
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| المؤلفون: | Manabu Kawada, Masaki Hatano, Naoko Kinoshita, Masayuki Igarashi, Tetsuya Someno, Yohko Yamazaki, Isao Momose, Akio Nomoto |
| المصدر: | The Journal of Antibiotics. 68:279-285 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Antineoplastic Agents, Pharmacology, urologic and male genital diseases, Streptomyces, Prostate cancer, Cell Line, Tumor, Drug Discovery, Androgen Receptor Antagonists, medicine, Humans, Receptor, Cytotoxicity, biology, Prostatic Neoplasms, biology.organism_classification, medicine.disease, Gene Expression Regulation, Neoplastic, Androgen receptor, Cinnamates, Receptors, Androgen, Cell culture, Cancer cell, Cancer research, Oligopeptides |
| الوصف: | Androgen receptor (AR) is a validated target in all clinical states of prostate cancer. Androprostamines A and B, the new inhibitors of androgen receptor, were isolated from Streptomyces sp. MK932-CF8. Their structures were determined by the spectroscopic analysis, degradation studies and synthesis. Androprostamines showed potent inhibitory effect against androgen-dependent growth of human prostate cancer cells without cytotoxicity and repressed the androgen-induced expression of AR-regulated genes. |
| تدمد: | 1881-1469 0021-8820 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e41b9e8eeaf9e0277b1e0363de1f1c https://doi.org/10.1038/ja.2014.135 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c6e41b9e8eeaf9e0277b1e0363de1f1c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18811469 00218820 |
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