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Changing of hepatitis C virus genotype patterns in France at the beginning of the third millenium: The GEMHEP GenoCII Study

التفاصيل البيبلوغرافية
العنوان: Changing of hepatitis C virus genotype patterns in France at the beginning of the third millenium: The GEMHEP GenoCII Study
المؤلفون: G. Thiefin, P. Chevallier, Ghassan Riachi, Françoise Stoll-Keller, V. Gerolami, B. Fouqueray, C. Silvain, Catherine Laffont, P. Couzigou, Christopher Payan, C. Chaput, Stanislas Pol, Armand Abergel, Michel Branger, Thomas Bourlet, Philippe Halfon, J.-J. Lefrère, Jacques Izopet, P. Sogni, Florence Grattard, Françoise Lunel-Fabiani, A. Charrois, M. Coudé, Michelle Martinot-Peignoux, Marc Bourlière, Pascale Trimoulet, Gilles Duverlie, Claudine Buffet-Janvresse, P. Opolon, M. Doffoel, Jean-Michel Pawlotsky, Marie-Laure Chaix, Jean-Didier Grangé, Marc Bogard, Christian Trepo, E. Plouvier, K. Barange, V. Brodard, Arielle R. Rosenberg, D. Cointe, Sophie Alain, N. Bled, Patrick Marcellin, V. Thibault, Isabelle Portal, Cécile Henquell, Lawrence Serfaty, Véronique Loustaud-Ratti, Françoise Roudot-Thoraval, G. Agius, A. Blanchi, Isabelle Fouchard-Hubert, Christophe Hézode
المساهمون: Service de santé publique [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service d'hépatologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de virologie et d'immunologie biologique, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, CHU Clermont-Ferrand, Service d'hépato-gastro-entérologie [APHP Henri Mondor], Biologie moléculaire et cellulaire des microorganismes (EA3175), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Limoges (UNILIM), Service de Bactériologie, Virologie, Hygiène [CHU Limoges], CHU Limoges, Laboratoire alphabio, Service d'Hépato-gastroentérologie, Assistance Publique - Hôpitaux de Marseille (APHM), Interaction virus-hôte et maladies du foie, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hépato-gastroentérologie, CHU Strasbourg-Hopital Civil, Laboratoire de Virologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Service d'hépatologie médicale [CHU Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Necker - Enfants Malades [AP-HP], Service d'hépatologie [Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Université Pierre et Marie Curie - Paris 6 (UPMC), Service d'hépatologie [CHU Saint-Antoine], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Beaujon-Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), CHU Saint-Antoine [APHP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Pierre et Marie Curie - Paris 6 (UPMC), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Diderot - Paris 7 ( UPD7 ) -Hôpital Beaujon, Biologie moléculaire et cellulaire des microorganismes ( EA3175 ), Université de Limoges ( UNILIM ) -Génomique, Environnement, Immunité, Santé, Thérapeutique ( GEIST FR CNRS 3503 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Limoges ( UNILIM ), Assistance Publique - Hôpitaux de Marseille ( APHM ), Institut National de la Santé et de la Recherche Médicale ( INSERM ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Saint-Antoine [APHP]
المصدر: Journal of Viral Hepatitis
Journal of Viral Hepatitis, 2005, 12 (4), pp.405-413. ⟨10.1111/j.1365-2893.2005.00605.x⟩
Journal of Viral Hepatitis, Wiley-Blackwell, 2005, 12 (4), pp.405-413. ⟨10.1111/j.1365-2893.2005.00605.x⟩
Journal of Viral Hepatitis, Wiley-Blackwell, 2005, 12 (4), pp.405-413. 〈10.1111/j.1365-2893.2005.00605.x〉
سنة النشر: 2005
مصطلحات موضوعية: Male, Cirrhosis, MESH : Genotype, Hepacivirus, [ SDV.MP.BAC ] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, medicine.disease_cause, Polymerase Chain Reaction, MESH : Hepacivirus, MESH: Genotype, Cohort Studies, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Genotype, Epidemiology, MESH : Female, MESH: Hepacivirus, MESH : Polymerase Chain Reaction, MESH: Cohort Studies, 0303 health sciences, education.field_of_study, Molecular Epidemiology, MESH: Middle Aged, MESH : Adult, Middle Aged, Hepatitis C, 3. Good health, [ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Infectious Diseases, MESH: RNA, Viral, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Coinfection, RNA, Viral, 030211 gastroenterology & hepatology, Female, France, Adult, medicine.medical_specialty, MESH : Male, Hepatitis C virus, Population, MESH : Cohort Studies, Biology, [ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, MESH : Epidemiology, Molecular, 03 medical and health sciences, MESH: Epidemiology, Molecular, Virology, medicine, MESH : RNA, Viral, Humans, MESH : Middle Aged, Risk factor, MESH : France, education, 030304 developmental biology, Hepatitis B virus, MESH: Hepatitis C, MESH: Humans, Hepatology, MESH : Humans, MESH: Adult, MESH: Polymerase Chain Reaction, MESH : Hepatitis C, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, MESH: Male, MESH: France, MESH: Female
الوصف: International audience; This cross-sectional study aimed to investigate, during a short period between 2000 and 2001, in a large population of patients with chronic hepatitis C, the epidemiological characteristics of hepatitis C virus (HCV) genotypes in France. Data from 26 referral centres, corresponding to 1769 patients with chronic hepatitis C were collected consecutively during a 6-month period. HCV genotyping in the 5'-non-coding region (NCR) was performed in each center using the line probe assay (LiPA, in 63% of cases), sequencing (25%) or primer-specific polymerase chain reaction (PCR) (12%). HCV genotypes 1a, 1b, 2, 3, 4, 5, non-subtyped 1 and mixed infection were found in 18, 27, 9, 21, 9, 3, 11 and 1% of our population, respectively. HCV genotype distribution was associated with gender, age, source and duration of infection, alanine aminotransferase (ALT) levels, cirrhosis, alcohol consumption, hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection. In multivariate analysis, only the source of infection was the independent factor significantly associated with genotype (P = 0.0001). In conclusion, this study shows a changing pattern of HCV genotypes in France, with i.v. drug abuse as the major risk factor, an increase of genotype 4, and to a lesser extent 1a and 5, and a decrease of genotypes 1b and 2. The modification of the HCV genotype pattern in France in the next 10 years may require new therapeutic strategies, and further survey studies.
تدمد: 1352-0504
1365-2893
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ee41f1b65d2b2e5f03d2c5006767ed
https://pubmed.ncbi.nlm.nih.gov/15985012
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....c6ee41f1b65d2b2e5f03d2c5006767ed
قاعدة البيانات: OpenAIRE
الوصف
تدمد:13520504
13652893