Effects of portal free fatty acid elevation on insulin clearance and hepatic glucose flux
| العنوان: | Effects of portal free fatty acid elevation on insulin clearance and hepatic glucose flux |
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| المؤلفون: | Hiroshi Uchino, Keyur Shah, Adria Giacca, Hidenori Yoshii, I. George Fantus, Neehar Gupta, Tony Kim, Andrea Mari, Tony K.T. Lam, Tracy Goh, Victor Z. Chong, Ryuzo Kawamori, C. Andrew Haber |
| المصدر: | American Journal of Physiology-Endocrinology and Metabolism. 290:E1089-E1097 |
| بيانات النشر: | American Physiological Society, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, Time Factors, Physiology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Endogeny, Fatty Acids, Nonesterified, chemistry.chemical_compound, Dogs, Insulin resistance, Physiology (medical), Internal medicine, medicine, Hyperinsulinemia, Animals, Insulin, chemistry.chemical_classification, Chemistry, Fatty acid, Glucose clamp technique, medicine.disease, Hormones, Portal System, Oleic acid, Glucose, Endocrinology, Liver, Glucose Clamp Technique, Oleic Acid, Hormone |
| الوصف: | We tested the hypothesis that, due to greater hepatic free fatty acid (FFA) load, portal delivery of FFAs, as in visceral obesity, induces hyperinsulinemia and increases endogenous glucose production to a greater extent than peripheral FFA delivery. For 5 h, 10 μeq·kg−1·min−1portal oleate ( n = 6), equidose peripheral oleate ( n = 5), or saline ( n = 6) were given intravenously to conscious dogs infused with a combination of portal and peripheral insulin to enable calculation of hepatic insulin clearance during a pancreatic euglycemic clamp. Peripheral FFAs were similar with both oleate treatments and were threefold greater than in controls. Portal FFAs were 1.5- to 2-fold greater with portal than with peripheral oleate. Peripheral insulin concentrations were greatest with portal oleate, intermediate with peripheral oleate ( P < 0.001 vs. portal oleate or controls), and lowest in controls, consistent with corresponding reductions in plasma insulin clearance and hepatic insulin clearance. Although endogenous glucose production did not differ between the two routes of oleate delivery, total glucose output (endogenous glucose production plus glucose cycling) was greater with portal than with peripheral oleate ( P < 0.001) despite the higher insulin levels. In conclusion, during euglycemic clamps in dogs, the main effect of short-term elevation in portal FFA is to generate peripheral hyperinsulinemia. This may, in the long term, contribute to the metabolic and cardiovascular risk of visceral obesity. |
| تدمد: | 1522-1555 0193-1849 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75476e182495bd61cd3abdfcf510f09 https://doi.org/10.1152/ajpendo.00306.2005 |
| رقم الأكسشن: | edsair.doi.dedup.....c75476e182495bd61cd3abdfcf510f09 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221555 01931849 |
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