Usefulness of ultrasensitive prostate-specific antigen assay for early detection of biochemical failure after radical prostatectomy
| العنوان: | Usefulness of ultrasensitive prostate-specific antigen assay for early detection of biochemical failure after radical prostatectomy |
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| المؤلفون: | Hisashi Hasumi, Hiroji Uemura, Masafumi Nakamura, Kiyoshi Fujinami, Shinpei Sugiura, Yasuhide Miyoshi, Masahiro Yao, Yoshinobu Kubota |
| المصدر: | International Journal of Urology. 12:1050-1054 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, Biochemical recurrence, medicine.medical_specialty, Urology, Biochemical failure, medicine.medical_treatment, Salvage therapy, Early detection, urologic and male genital diseases, Sensitivity and Specificity, Prostate cancer, Humans, Medicine, Treatment Failure, Aged, Retrospective Studies, Prostatectomy, Receiver operating characteristic, business.industry, Prostatic Neoplasms, Prostate-Specific Antigen, Prognosis, medicine.disease, Early Diagnosis, Neoplasm Recurrence, Local, business, Nadir (topography) |
| الوصف: | Background: In order to assess whether the prostate-specific antigen (PSA) nadir obtained with an ultrasensitive PSA assay can be used as a prognostic indicator for patients undergoing radical prostatectomy, we investigated it retrospectively. Methods: Between October 1997 and July 2003, 46 patients underwent radical prostatectomy for prostate cancer at our institution. None of them received preoperative treatment. Levels of PSA were measured with an ultrasensitive PSA assay every 1–3 months after prostatectomy. Biochemical recurrence was defined as a PSA level of 0.2 ng/mL or higher. Results: There was a significant difference in PSA nadir between the biochemical recurrence group and the no recurrence group (P < 0.001). The receiver operating characteristics (ROC) curve gave an optimal cut-off value for PSA nadir of 0.01 ng/mL, demonstrating a significant difference in biochemical recurrence after radical prostatectomy. No patient with a PSA nadir level |
| تدمد: | 1442-2042 0919-8172 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7635f3342e26b758e95d86c141b7fd9 https://doi.org/10.1111/j.1442-2042.2005.01202.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....c7635f3342e26b758e95d86c141b7fd9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14422042 09198172 |
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