The role of primary inguinal surgical debulking for locally advanced penile cancer followed by reconstruction with myocutaneous flap
| العنوان: | The role of primary inguinal surgical debulking for locally advanced penile cancer followed by reconstruction with myocutaneous flap |
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| المؤلفون: | Marcio Ginsberg, Daniel Hampl, Antonio Augusto Ornellas, Paulo Ornellas, Nelson Koifman, Leandro Koifman, Rodrigo Barros de Castro |
| المصدر: | International braz j urol v.47 n.6 2021 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU International braz j urol, Volume: 47, Issue: 6, Pages: 1162-1175, Published: 01 OCT 2021 International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology International Brazilian Journal of Urology, Vol 47, Iss 6, Pp 1162-1175 (2021) |
| بيانات النشر: | FapUNIFESP (SciELO), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Gracilis flap, medicine.medical_specialty, business.industry, Adjuvant chemotherapy, Urology, Penile Neoplasm, Locally advanced, medicine.disease, Debulking, Myocutaneous Flap, Diseases of the genitourinary system. Urology, Surgery, medicine, Humans, Penile cancer, Original Article, RC870-923, Reconstructive Surgical Procedures, High incidence, business, Tensor fascia lata flap, Penile Neoplasms, Neoplasm Staging |
| الوصف: | Purpose: To evaluate surgical complications and oncological outcomes of patients submitted to primary radical inguinal surgical debulking (PRISD) and myocutaneous pediculate flap reconstruction (MPFR) for locally advanced penile cancer (PC). Materials and Methods: Forty-two patients with ulcerated and/or fixed bulky inguinal masses underwent unilateral or bilateral PRISD with MPFR. Tensor fascia lata flap (TFL) was the standard of care for all patients. Additional use of the gracilis flap (GF) was carried out when necessary. Contra-lateral radical inguinal lymphadenectomy (RIL) was conduced when PRISD was performed unilaterally. Surgical complications were analyzed and stratified into minor and major according to the Bevan-Thomas classification. Adjunctive treatments were assessed and oncological outcomes analyzed. Results: Of the 42 patients evaluated, 10 (23.8%) underwent bilateral PRISD and 32 (76.2%) unilateral PRISD with contra-lateral RIL, totaling 84 lymphadenectomies. A total of 62 MPFRs were performed, 52 with TFL and 10 with GF. A total of 53 complications were identified, 49 related to PRISD with MPFR and 4 to RIL. Adjuvant chemotherapy was carried out in 16 patients. Median follow-up was 10.8 months with a median overall survival (OS) of 14.0 months against 6.0 months (p=0.006) for patients submitted to PRISD with adjuvant chemotherapy in relation to surgery alone. Conclusions: PRISD alone for advanced loco-regional PC is unlikely to promote long-term survival, although it can lead to temporary local control of the disease. Despite the feasibility of the procedure, it is related to high incidence of complications. Surgical treatment with adjuvant chemotherapy is associated with improved OS. |
| وصف الملف: | text/html |
| تدمد: | 1677-6119 1677-5538 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7638865bb3df41afd0af9cad7bcf2f3 https://doi.org/10.1590/s1677-5538.ibju.2021.0169 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c7638865bb3df41afd0af9cad7bcf2f3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16776119 16775538 |
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