A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis
| العنوان: | A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis |
|---|---|
| المؤلفون: | Xiang-Hong Jing, Mingzhou Fu, Lu Qi, Yan-Qing Wang, Wei Yang, Yang-Shuai Su, Shenbin Liu, Qiufu Ma, Zhi-Fu Wang |
| المصدر: | Nature |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Mice, Transgenic, Stimulation, Sensory system, Abdominal fascia, Autonomic Nervous System, Somatosensory system, Article, Mice, Adrenal Glands, Reflex, Animals, Medicine, Multidisciplinary, business.industry, Autonomic Pathways, Vagus Nerve, Efferent Neuron, Hindlimb, Mice, Inbred C57BL, Electroacupuncture, Body region, business, Acupuncture Points, Neuroscience |
| الوصف: | Somatosensory autonomic reflexes allow electroacupuncture stimulation (ES) to modulate body physiology at distant sites1–6 (for example, suppressing severe systemic inflammation6–9). Since the 1970s, an emerging organizational rule about these reflexes has been the presence of body-region specificity1–6. For example, ES at the hindlimb ST36 acupoint but not the abdominal ST25 acupoint can drive the vagal–adrenal anti-inflammatory axis in mice10,11. The neuroanatomical basis of this somatotopic organization is, however, unknown. Here we show that PROKR2Cre-marked sensory neurons, which innervate the deep hindlimb fascia (for example, the periosteum) but not abdominal fascia (for example, the peritoneum), are crucial for driving the vagal–adrenal axis. Low-intensity ES at the ST36 site in mice with ablated PROKR2Cre-marked sensory neurons failed to activate hindbrain vagal efferent neurons or to drive catecholamine release from adrenal glands. As a result, ES no longer suppressed systemic inflammation induced by bacterial endotoxins. By contrast, spinal sympathetic reflexes evoked by high-intensity ES at both ST25 and ST36 sites were unaffected. We also show that optogenetic stimulation of PROKR2Cre-marked nerve terminals through the ST36 site is sufficient to drive the vagal–adrenal axis but not sympathetic reflexes. Furthermore, the distribution patterns of PROKR2Cre nerve fibres can retrospectively predict body regions at which low-intensity ES will or will not effectively produce anti-inflammatory effects. Our studies provide a neuroanatomical basis for the selectivity and specificity of acupoints in driving specific autonomic pathways. Neuroanatomical findings demonstrate why electroactupuncture at only specific acupoints can drive the vagal–adrenal axis and treat inflammation in mice. |
| تدمد: | 1476-4687 0028-0836 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7757a871701ef59860ebd75f08bc659 https://doi.org/10.1038/s41586-021-04001-4 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c7757a871701ef59860ebd75f08bc659 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14764687 00280836 |
|---|