Alterations of intracellular pH homeostasis in apoptosis: origins and roles
| العنوان: | Alterations of intracellular pH homeostasis in apoptosis: origins and roles |
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| المؤلفون: | V Lecureur, Laurence Huc, D Lagadic-Gossmann |
| المساهمون: | Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), Lagadic-Gossmann, D, Université de Rennes (UR) |
| المصدر: | Cell Death and Differentiation Cell Death and Differentiation, Nature Publishing Group, 2004, 11 (9), pp.953-61. ⟨10.1038/sj.cdd.4401466⟩ Cell Death and Differentiation 9 (11), 953-61. (2004) Cell Death and Differentiation, 2004, 11 (9), pp.953-61. ⟨10.1038/sj.cdd.4401466⟩ |
| بيانات النشر: | HAL CCSD, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Programmed cell death, Cytoplasm, Sodium-Hydrogen Exchangers, MAP Kinase Signaling System, Intracellular pH, [SDV]Life Sciences [q-bio], Endogeny, Apoptosis, Biology, Models, Biological, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Animals, Homeostasis, Humans, Molecular Biology, Cation Transport Proteins, 030304 developmental biology, 0303 health sciences, Sodium-Hydrogen Exchanger 1, Cell Death, Cell growth, Tumor Necrosis Factor-alpha, Membrane Proteins, Transporter, Cell Biology, Hydrogen-Ion Concentration, Cell biology, Mitochondria, Biochemistry, 030220 oncology & carcinogenesis, Function (biology) |
| الوصف: | International audience; Intracellular pH (pHi) has an important role in the maintenance of normal cell function, and hence this parameter has to be tightly controlled within a narrow range, largely through the activity of transporters located at the plasma membrane. These transporters can be modulated by endogenous or exogenous molecules as well as, in some pathological situations, leading to pHi changes that have been implicated in both cell proliferation and cell death. Whereas intracellular alkalinization seems to be a common feature of proliferative processes, the precise role of pHi in apoptosis is still unclear. The present review gathers the most recent advances along with previous data on both the origin and the role of pHi alterations in apoptosis and highlights the major concerns that merit further research in the future. Special attention is given to the possible role played by pHi-regulating transporters. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1350-9047 1476-5403 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c784eb3ed2a57b5c9c85da353e6d48e9 https://hal.inrae.fr/hal-02683409/document |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c784eb3ed2a57b5c9c85da353e6d48e9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13509047 14765403 |
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