In this study, binocular interaction in guinea pigs is evaluated using bioelectrical activities. A difference potential, as evidence of an interaction, is calculated by subtracting the sum of visual-evoked potentials recorded by left and right monocular visual stimulations from the potential recorded by binocular stimulation. A negative monophasic wave with an average amplitude of 15.1 microV and an average latency of 106 ms is observed in the difference potential. This finding implies that the P100 is the main guinea pig visual-evoked potential wave that is affected by binocular interaction. Binocular interaction is also observed in the waves N75 and N140, although with a smaller amplitude. No interaction is observed in the segments of P55 and P200 waves.
