Autologous stem cell transplantation in chronic myeloid leukaemia using Philadelphia chromosome negative blood progenitors mobilised with hydroxyurea and G-CSF
| العنوان: | Autologous stem cell transplantation in chronic myeloid leukaemia using Philadelphia chromosome negative blood progenitors mobilised with hydroxyurea and G-CSF |
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| المؤلفون: | Gareth J. Morgan, Guy Pratt, D. L. Barnard, G. M. Smith, Andy C. Rawstron, Roderick J. Johnson |
| المصدر: | Bone Marrow Transplantation. 21:455-460 |
| بيانات النشر: | Springer Science and Business Media LLC, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Transplantation Conditioning, medicine.medical_treatment, Antineoplastic Agents, Philadelphia chromosome, Transplantation, Autologous, Gastroenterology, Autologous stem-cell transplantation, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Internal medicine, Granulocyte Colony-Stimulating Factor, medicine, Humans, Hydroxyurea, Autologous transplantation, Philadelphia Chromosome, Progenitor cell, Transplantation, Chemotherapy, business.industry, Hematopoietic Stem Cell Transplantation, Hematology, Middle Aged, medicine.disease, Combined Modality Therapy, Surgery, Regimen, Treatment Outcome, Female, Stem cell, business |
| الوصف: | Autologous transplantation in CML has been a focus of interest over the last few years. Determining the indications, optimal timing and method for this procedure remains controversial. One approach has been the mobilisation of Philadelphia chromosome negative (Ph-) peripheral blood stem cells following high-dose chemotherapy as a method of purging the graft. We have described a mobilisation regimen of 7 days of hydroxyurea followed by G-CSF and have shown it to be substantially less toxic than other methods. We now report further experience with this technique in a total of 18 patients and the outcome of transplantation in seven patients using cells so-derived. Following mobilisation, approximately a third of patients had 100% Ph-collections and half had less than 50% Ph+ collections. All patients were 100% Ph+ prior to mobilisation. Six out of seven transplanted patients showed sustained engraftment and two of these patients became 18 and 34% Ph+ 3 months post-transplant. Five patients remain alive and well 13 to 25 months post-autograft. In conclusion, we have developed a well-tolerated regimen for Ph- PBSC mobilisation and have demonstrated that such cells are capable of sustained engraftment and of producing significant cytogenetic responses. |
| تدمد: | 1476-5365 0268-3369 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c812f469df37754cd00223a1a4d1c3bc https://doi.org/10.1038/sj.bmt.1701118 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c812f469df37754cd00223a1a4d1c3bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765365 02683369 |
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