Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome
| العنوان: | Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome |
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| المؤلفون: | Chung Hwan Hong, Myoung Seok Ko, Jae Hyun Kim, Hyunkyung Cho, Chi-Ho Lee, Ji Eun Yoon, Ji-Young Yun, In-Jeoung Baek, Jung Eun Jang, Seung Eun Lee, Yun Kyung Cho, Ji Yeon Baek, Soo Jin Oh, Bong Yong Lee, Joon Seo Lim, Jongkook Lee, Sean M. Hartig, Laura Conde de la Rosa, Carmen Garcia-Ruiz, Ki-Up Lee, Jose C. Fernández-Checa, Ji Woong Choi, Sanghee Kim, Eun Hee Koh |
| المساهمون: | National Research Foundation of Korea, Ministry of Education, Science and Technology (South Korea), Ministry of Science, ICT and Future Planning (South Korea), Ministry of Trade, Industry and Energy (South Korea), Ministry of Health and Welfare (South Korea), Asan Institute for Life Sciences, Government of South Korea, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España), Instituto de Salud Carlos III, National Institute on Alcohol Abuse and Alcoholism (US), Generalitat de Catalunya, Fundación BBVA, Fundació La Marató de TV3 |
| المصدر: | Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 925-947 (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Hepatology, Inflammasomes, Gastroenterology, Hepatic Macrophages, RC799-869, Diseases of the digestive system. Gastroenterology, Functional Antagonist, S1P, Mice, Non-alcoholic Fatty Liver Disease, Caþþ, Ca++, NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Humans, Sphingosine-1-Phosphate Receptors |
| الوصف: | Type 4 sphingosine-1-phosphate receptor, which mediates the activation of the Nod-like receptor (NLR) family pyrin domain containing 3 inflammasome, emerges as a new therapeutic target for nonalcoholic steatohepatitis. We developed a selective functional antagonist for type 4 sphingosine-1-phosphate receptor (SLB736), which protected mice against nonalcoholic steatohepatitis and fibrosis Supported by the National Research Foundation of Korea, funded by the Ministry of Education, Science, and Technology, Korea, grants 2017R1E1A1A01073206 (K.-U.L.), 2020R1A2B5B02098524 (E.H.K.), 2019R1C1C1003567 (J.-Y.Y.), and 2021R1A2C1005520 (J.W.C.), the Korea Drug Development Fund funded by the Ministry of Science and ICT, Ministry of Trade, Industry, and Energy, and Ministry of Health and Welfare grant KDDF-201406-03 (K.-U.L.), and Asan Institute for Life Sciences, Korea, grant 2020IP0016-1 (E.H.K.). This work also was supported by the Mid-Career Researcher Programs grant NRF-2019R1A2C2009905 (S.K.) of the National Research Foundation of Korea, funded by the Government of Korea (MSIP); and by grants PID2019-111669RB-I00 and PID2020-115055RB-I00 from Plan Nacional de Investigación y Desarrollo, Spain, by the Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Spain; by grant P50AA011999 from the Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis funded by National Institute of Alcohol Abuse and Alcoholism; by Agency for Administration of University and Research Grants of the Generalitat de Cataluña SGR-2017-1112 and the “ER stress-mitochondrial cholesterol axis in obesity-associated insulin resistance and comorbidities” Ayudas Fundación Banco Bilbao Vizcaya Argentaria a Equipos de Investigación Científica 2017, the Red Nacional 2018-102799-T de Enfermedades Metabólicas y Cáncer, and by project 201916/31 Contribution of mitochondrial oxysterol and bile acid metabolism to liver carcinogenesis 2019 by Fundació Marato Televisión 3. None of the funders had a role in the study design, collection, analysis, or interpretation of data. |
| تدمد: | 2352-345X 0107-3206 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82a8428b789a3372c95277259137e1a http://hdl.handle.net/10261/288649 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c82a8428b789a3372c95277259137e1a |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 2352345X 01073206 |
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