Modulators of Redox Metabolism in Head and Neck Cancer
| العنوان: | Modulators of Redox Metabolism in Head and Neck Cancer |
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| المؤلفون: | Sarah M. Planchon, Xiumei Huang, Edward A. Motea, David A. Boothman, Xiaofei Chen, Jade Mims, Naveen Singh, Muhammad Shaalan Beg, Melissa L. Kemp, Allen W. Tsang, Cristina M. Furdui, Mercedes Porosnicu |
| المصدر: | Antioxidants & Redox Signaling. 29:1660-1690 |
| بيانات النشر: | Mary Ann Liebert Inc, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, medicine.medical_specialty, Physiology, medicine.medical_treatment, Clinical Biochemistry, Disease, medicine.disease_cause, Biochemistry, 03 medical and health sciences, Quality of life, Internal medicine, medicine, Animals, Humans, Epidermal growth factor receptor, Molecular Biology, General Environmental Science, biology, business.industry, Head and neck cancer, Computational Biology, Cell Biology, Forum Review Articles, medicine.disease, Radiation therapy, Clinical trial, 030104 developmental biology, Head and Neck Neoplasms, Immunology, biology.protein, General Earth and Planetary Sciences, business, Oxidation-Reduction, Adjuvant, Oxidative stress |
| الوصف: | Significance: Head and neck squamous cell cancer (HNSCC) is a complex disease characterized by high genetic and metabolic heterogeneity. Radiation therapy (RT) alone or combined with systemic chemotherapy is widely used for treatment of HNSCC as definitive treatment or as adjuvant treatment after surgery. Antibodies against epidermal growth factor receptor are used in definitive or palliative treatment. Recent Advances: Emerging targeted therapies against other proteins of interest as well as programmed cell death protein 1 and programmed death-ligand 1 immunotherapies are being explored in clinical trials. Critical Issues: The disease heterogeneity, invasiveness, and resistance to standard of care RT or chemoradiation therapy continue to constitute significant roadblocks for treatment and patients' quality of life (QOL) despite improvements in treatment modality and the emergence of new therapies over the past two decades. Future Directions: As reviewed here, alterations in redox metabolism occur at all stages of HNSCC management, providing opportunities for improved prevention, early detection, response to therapies, and QOL. Bioinformatics and computational systems biology approaches are key to integrate redox effects with multiomics data from cells and clinical specimens and to identify redox modifiers or modifiable target proteins to achieve improved clinical outcomes. Antioxid. Redox Signal. |
| تدمد: | 1557-7716 1523-0864 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c843ef2a765a7a28d6497f60bb3db3f1 https://doi.org/10.1089/ars.2017.7423 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c843ef2a765a7a28d6497f60bb3db3f1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577716 15230864 |
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