Effects of training and albuterol on pain and fatigue in facioscapulohumeral muscular dystrophy
| العنوان: | Effects of training and albuterol on pain and fatigue in facioscapulohumeral muscular dystrophy |
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| المؤلفون: | Eline Lindeman, Gijs Bleijenberg, E.L. van der Kooi, Jan C.M. Hendriks, Joke S. Kalkman, George W. Padberg, B.G.M. van Engelen |
| المصدر: | Journal of Neurology Journal of Neurology, 254, 7, pp. 931-40 Journal of Neurology, 254, 931-40 |
| بيانات النشر: | Steinkopff-Verlag, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, Neurology, Time Factors, Physical fitness, law.invention, Randomized controlled trial, law, Sickness Impact Profile, Effective Primary Care and Public Health [EBP 3], Perception and Action [DCN 1], Facioscapulohumeral muscular dystrophy, Fatigue, Pain Measurement, Human Movement & Fatigue [NCEBP 10], Original Communication, exercise therapy, Psychological determinants of chronic illness [NCEBP 8], Adrenergic beta-Agonists, Middle Aged, Combined Modality Therapy, Muscular Dystrophy, Facioscapulohumeral, Female, Functional Neurogenomics [DCN 2], medicine.drug, Adult, medicine.medical_specialty, Strength training, Clinical Neurology, facioscapulohumeral muscular dystrophy, Pain, Physical exercise, Statistics, Nonparametric, Quality of Care [ONCOL 4], Physical medicine and rehabilitation, Double-Blind Method, Interventional oncology [UMCN 1.5], medicine, Humans, Pain Management, Albuterol, Muscle Strength, Exercise, business.industry, medicine.disease, Neuromuscular development and genetic disorders [UMCN 3.1], Clinical trial, Evaluation of complex medical interventions [NCEBP 2], Physical Fitness, Salbutamol, Physical therapy, Neurology (clinical), Microbial pathogenesis and host defense [UMCN 4.1], business |
| الوصف: | Contains fulltext : 51802.pdf (Publisher’s version ) (Closed access) BACKGROUND : We recently reported a randomised controlled trial on the efficacy of strength training and the beta2-adrenergic agonist albuterol in patients with facioscapulohumeral muscular dystrophy (FSHD). Strength training and albuterol appeared safe interventions with limited positive effect on muscle strength and volume. We concurrently explored the prevalence and the characteristics of pain and fatigue in the participating FSHD patients, because these are probably underreported but clinically relevant symptoms in this disorder. Next, we studied the effects of albuterol and strength training on pain, experienced fatigue, health-related functional status and psychological distress. METHODS : Sixty-five patients were randomised to strength training of elbow flexors and ankle dorsiflexors or non-training. After 26 weeks, albuterol (sustained-release, 8 mg bid) was added in a randomised, double-blind, placebo-controlled design. Outcomes comprised self-reported pain, experienced fatigue, functional status and psychological distress obtained with validated questionnaires at 52 weeks. RESULTS : Eighty percent of patients reported chronic persistent or periodic, multifocal pains. Thirty-four percent of the participants were severely fatigued. Strength training and albuterol failed to have a significant effect on all outcomes. CONCLUSIONS : Pain and fatigue are important features in FSHD. Strength training and albuterol do not have a positive or negative effect on pain, experienced fatigue, functional status and psychological distress. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1432-1459 0340-5354 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c861d59a701328caba20bcf9773aa2b7 http://europepmc.org/articles/PMC2779375 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c861d59a701328caba20bcf9773aa2b7 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321459 03405354 |
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