Identification of immunologic and clinical characteristics that predict inflammatory response to C. Novyi-NT bacteriolytic immunotherapy
| العنوان: | Identification of immunologic and clinical characteristics that predict inflammatory response to C. Novyi-NT bacteriolytic immunotherapy |
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| المؤلفون: | Linping Zhang, Jeffrey N. Bryan, Saurabh Saha, Yan Zhang, Sandra M. Axiak-Bechtel, Amy E. DeClue, David Tung |
| المصدر: | BMC Veterinary Research, Vol 14, Iss 1, Pp 1-10 (2018) BMC Veterinary Research |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, 040301 veterinary sciences, medicine.medical_treatment, Inflammatory response, Immunology, Inflammation, Canine, 0403 veterinary science, 03 medical and health sciences, Immune system, Dogs, Heart rate, medicine, Animals, Dog Diseases, Cancer, Clostridium, lcsh:Veterinary medicine, General Veterinary, business.industry, 04 agricultural and veterinary sciences, General Medicine, Immunotherapy, Hypoxia (medical), medicine.disease, 030104 developmental biology, Peripheral blood lymphocyte, Clostridium Infections, lcsh:SF600-1100, Female, medicine.symptom, business, Research Article |
| الوصف: | Background Clostridium novyi-NT (CNV-NT), has shown promise as a bacterolytic therapy for solid tumors in mouse models and in dogs with naturally developing neoplasia. Factors that impact the immunologic response to therapy are largely unknown. The goal of this pilot study was to determine if plasma immune biomarkers, immune cell function, peripheral blood cytological composition and tumor characteristics including evaluation of a PET imaging surrogate of tumor tissue hypoxia could predict which dogs with naturally developing naïve neoplasia would develop an inflammatory response to CNV-NT. Results Dogs that developed an inflammatory response to CNV-NT had a higher heart rate, larger gross tumor volume, greater tumor [64Cu]ATSM SUVMax, increased constitutive leukocyte IL-10 production, more robust NK cell-like function and greater peripheral blood lymphocyte counts compared to dogs that did not develop an inflammatory response to CNV-NT. Of these, unstimulated leukocyte IL-10 production, heart rate, and gross tumor volume appeared to be the best predictors of which dogs will develop an inflammatory response to CNV-NT. Conclusions Development of inflammation in response to CNV-NT is best predicted by pretreatment unstimulated leukocyte IL-10 production, heart rate, and gross tumor volume. |
| اللغة: | English |
| تدمد: | 1746-6148 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b60aaf7864c1e8ffaf6a779f94576d http://link.springer.com/article/10.1186/s12917-018-1424-1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c8b60aaf7864c1e8ffaf6a779f94576d |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 17466148 |
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