A single nucleotide polymorphism in the IL1RL1 gene is associated with Behcet’s disease in a Chinese Han population
| العنوان: | A single nucleotide polymorphism in the IL1RL1 gene is associated with Behcet’s disease in a Chinese Han population |
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| المؤلفون: | Shanshan Jia, Xinshu Liu, Meifen Zhang, Pei-Zeng Yang, Yongzhe Li, Si Chen, Fei Gao, Chan Zhao, Ziyan Wu, Minghang Pei |
| المصدر: | Int J Ophthalmol International Journal of Ophthalmology, Vol 14, Iss 9, Pp 1315-1320 (2021) |
| بيانات النشر: | Press of International Journal of Ophthalmology (IJO Press), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Investigation, IL1RL1 Gene, Genetics, Candidate gene, business.industry, IL1RL1, Single-nucleotide polymorphism, Behcet's disease, RE1-994, medicine.disease, il33, behcet's disease, Pathogenesis, Ophthalmology, single nucleotide polymorphism, Genetic model, Genotype, chinese han population, Medicine, il1rl1, business |
| الوصف: | AIM: To explore the association of single nucleotide polymorphisms (SNPs) in the IL33/IL1RL1 gene region with the susceptibility to Behcet’s disease (BD) in a Chinese Han population. METHODS: A total of eight SNPs in the candidate gene region (rs11792633, rs7025417, rs10975519 and rs1048274 in IL33; rs2310220, rs12712142, rs13424006 and rs3821204 in IL1RL1) were genotyped in783 BD patients and 701 healthy controls by the Sequenom Mass Array iPLEX platform. RESULTS: A statistically significant association was observed between IL1RL1 rs12712142 and BD patients. The frequency of IL1RL1 rs12712142 variant allele A was significantly lower in BD patients than that in controls (OR=0.8, 95%CI: 0.69-0.94, Pc=0.039); the genotype distribution (Pc=0.043) and additive and dominant genetic model analyses (OR=0.8, 95%CI: 0.69-0.94, Pc=0.040 and OR=0.72, 95%CI: 0.58-0.88, Pc=0.011) also indicated a strong association between rs12712142 and BD patients. CONCLUSION: This is the first study to reveal the association between IL1RL1 rs12712142 variant allele A and the decreased risk of BD in the Chinese Han population, indicating a protective role of IL1RL1 in the pathogenesis of BD. |
| تدمد: | 2227-4898 2222-3959 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c3ccbbaecd741e2523a05a4161166c https://doi.org/10.18240/ijo.2021.09.04 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c8c3ccbbaecd741e2523a05a4161166c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22274898 22223959 |
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