أعرض في EDS

Home-based exercise in autoimmune myasthenia gravis: A randomized controlled trial

التفاصيل البيبلوغرافية
العنوان: Home-based exercise in autoimmune myasthenia gravis: A randomized controlled trial
المؤلفون: Simone Birnbaum, Benjamin Rohaut, Judith Mendelson, Francis Bolgert, R. Le Panse, Diane Friedman, Yasmine Domingo, Nicolas Weiss, Bernard Clair, Anthony Behin, Isabelle Ledoux, Frédérique Truffault, Nawal Derridj Ait-Younes, Mélinée Frenkian, Sandra Misdrahi, Guillaume Bassez, Cécilia Orblin Bedos, Jacques Ropers, Tarek Sharshar, B. Eymard, Pierre Portero, S Berrih-Aknin, Sophie Demeret, Philippe Aegerter, Sonia Berrih-Aknin, Estelle Louët, Linda William, Pascal Laforêt, Philippe Thoumie, Raphaël Porcher, Marcela Gargiulo, J.Y. Hogrel, Sylvie Azerad, Elodie Soler, Asmaa Jobic
المساهمون: Institute of Myology Paris France
المصدر: Neuromuscular Disorders
Neuromuscular Disorders, Elsevier, 2021, 31 (8), pp.726-735. ⟨10.1016/j.nmd.2021.05.002⟩
بيانات النشر: HAL CCSD, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Adult, Male, Quality of life, medicine.medical_specialty, Randomization, Exacerbation, [SDV]Life Sciences [q-bio], Rowing, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Autoimmune disease, Clinical endpoint, Humans, Medicine, Prospective Studies, Home based exercise, Myasthenia gravis, Exercise, Genetics (clinical), Aged, Exercise Tolerance, business.industry, Middle Aged, medicine.disease, Exercise Therapy, 3. Good health, Neurology, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Physical therapy, Female, Neurology (clinical), business, 030217 neurology & neurosurgery
الوصف: International audience; The tolerance of exercise and its effects on quality of life in myasthenia gravis are not currently backed up by strong evidence. The aim of this study was to determine whether exercise as an adjunct therapy is well tolerated and can improve health-related quality of life (HRQoL) in stabilized, generalized autoimmune myasthenia gravis (gMG). We conducted a parallel-group, multi-center prospective RCT using computer-generated block randomization. Adults with stabilized, gMG, and no contra-indication to exercise, were eligible. Participants received usual care alone or usual care and exercise. The exercise intervention consisted of 3-weekly 40 min sessions of an unsupervised, moderate-intensity home rowing program over 3 months. The primary endpoint was the change in HRQoL from randomization to postintervention. Assessor-blinded secondary endpoints were exercise tolerance and effects on clinical, psychological and immunological status. Of 138 patients screened between October 2014 and July 2017, 45 were randomly assigned to exercise (n = 23) or usual care (n = 20). Although exercise was well tolerated, the intention-to-treat analysis revealed no evidence of improved HRQoL compared to usual care (MGQOL-15-F; mean adjusted between-groups difference of-0.8 points, 95%CI-5.4 to 3.7). Two patients hospitalized for MG exacerbation were from the usual care group.
اللغة: English
تدمد: 0960-8966
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8cd47068b252db3dfb3e52a6d4cec5a
https://hal.archives-ouvertes.fr/hal-03442076
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....c8cd47068b252db3dfb3e52a6d4cec5a
قاعدة البيانات: OpenAIRE
الوصف
تدمد:09608966