Improvements in Health-Related Quality of Life With Electroconvulsive Therapy
العنوان: | Improvements in Health-Related Quality of Life With Electroconvulsive Therapy |
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المؤلفون: | Jonathan Downar, Sidney H. Kennedy, Uros Rakita, Alastair J. Flint, Kirsten Penner-Goeke, Peter Giacobbe, Kfir Feffer |
المصدر: | The Journal of ECT. 34:87-94 |
بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2018. |
سنة النشر: | 2018 |
مصطلحات موضوعية: | Male, medicine.medical_specialty, medicine.medical_treatment, Treatment outcome, Neuroscience (miscellaneous), MEDLINE, behavioral disciplines and activities, 03 medical and health sciences, 0302 clinical medicine, Electroconvulsive therapy, Quality of life (healthcare), mental disorders, Humans, Medicine, Electroconvulsive Therapy, Intensive care medicine, Health related quality of life, Depressive Disorder, Major, Antidepressant efficacy, business.industry, 030227 psychiatry, Psychiatry and Mental health, Treatment Outcome, Meta-analysis, Quality of Life, Female, business, 030217 neurology & neurosurgery |
الوصف: | Although the antidepressant efficacy of ECT is well documented, patient-reported outcomes after this treatment are less well characterized. The aims of the current meta-analysis are to quantify the impact of an acute course of ECT on health-related quality of life (HRQoL) and to identify related moderators, specifically post-ECT depressive symptom remission and patient age.We searched PubMed, PsycINFO, and Web of Science databases for randomized and nonrandomized studies that report on changes in HRQoL measures after an acute course of ECT. Only studies that used the Medical Outcomes Study Short Form 36 (SF-36) instrument were included. A random effects model using the Hedges' g effect size was used in calculating the pre-post ECT outcomes on all 8 SF-36 subscales and the SF-36 total scores including the physical and mental composite scores. Subgroup analyses were conducted using remission status and age as moderators.Four studies contributed to this analysis. Significant improvements across all subscales of the SF-36 were observed. Large and very large effect sizes were present for both the SF-36 physical component score (PCS) and mental health component score (MCS), with the change in MCS being statistically superior to the PCS (MCS, Hedges' g = 1.28; 95% confidence interval, 1.15-1.42; PCS, Hedges' g = 0.97; 95% confidence interval, 0.86-1.07). Medium, large, and very large effect sizes were observed for SF-36 subscales scores. Post-ECT depression remission status was related to HRQoL improvement, with statistically significant differences present between remitters and nonremitters for PCS, MCS, and most SF-36 subscale scores. No significant differences were observed in improvement in HRQoL with ECT based on patient age.An acute course of ECT for depressive symptoms produces medium to very large effect size improvements in HRQoL across multiple components and subscales measured by the SF-36. The magnitude of the effects reported by ECT patients is greater than those that have been reported in other open-label studies of brain stimulation techniques. This study confirms that ECT plays a vital role in the treatment of the most severely ill patients with depressive disorders. |
تدمد: | 1533-4112 1095-0680 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e1b81d437ae7a0cc697e84923bd06f https://doi.org/10.1097/yct.0000000000000486 |
رقم الأكسشن: | edsair.doi.dedup.....c8e1b81d437ae7a0cc697e84923bd06f |
قاعدة البيانات: | OpenAIRE |
تدمد: | 15334112 10950680 |
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