A Global, Evidence-Based Consensus on the Definition of Gastroesophageal Reflux Disease in the Pediatric Population
| العنوان: | A Global, Evidence-Based Consensus on the Definition of Gastroesophageal Reflux Disease in the Pediatric Population |
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| المؤلفون: | Yvan Vandenplas, Susan R. Orenstein, Colin D. Rudolph, Seiichi Kato, Eric Hassall, Benjamin D. Gold, Nimish Vakil, Philip M. Sherman, Sibylle Koletzko, Ulysses Fagundes-Neto |
| المصدر: | The American Journal of Gastroenterology. 104:1278-1295 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Canada, medicine.medical_specialty, Evidence-based practice, Adolescent, Delphi Technique, International Cooperation, MEDLINE, Disease, Pediatrics, Sensitivity and Specificity, Gastroenterology, Internal medicine, Humans, Medicine, Child, Intensive care medicine, Evidence-Based Medicine, Hepatology, business.industry, Esophageal disease, digestive, oral, and skin physiology, Reflux, Evidence-based medicine, medicine.disease, digestive system diseases, El Niño, Child, Preschool, Gastroesophageal Reflux, Female, business, Pediatric population |
| الوصف: | To develop an international consensus on the definition of gastroesophageal reflux disease (GERD) in the pediatric population.Using the Delphi process, a set of statements was developed and voted on by an international panel of eight pediatric gastroenterologists. Statements were based on systematic literature searches using Medline, EMBASE, and CINAHL. Voting was conducted using a six-point scale, with consensus defined, a priori, as agreed by 75% of the group. The strength of each statement was assessed using the GRADE system.There were four rounds of voting. In the final vote, consensus was reached on 98% of the 59 statements. In this vote, 95% of the statements were accepted by seven of eight voters. Consensus items of particular note were: (i) GERD is present when reflux of gastric contents causes troublesome symptoms and/or complications, but this definition is complicated by unreliable reporting of symptoms in children under the age of approximately 8 years; (ii) histology has limited use in establishing or excluding a diagnosis of GERD; its primary role is to exclude other conditions; (iii) Barrett's esophagus should be defined as esophageal metaplasia that is intestinal metaplasia positive or negative; and (iv) extraesophageal conditions may be associated with GERD, but for most of these conditions causality remains to be established.The consensus statements that comprise the Definition of GERD in the Pediatric Population were developed through a rigorous process. These statements are intended to be used for the development of future clinical practice guidelines and as a basis for clinical trials. |
| تدمد: | 1572-0241 0002-9270 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e227788e98fd37b1645d44754aa591 https://doi.org/10.1038/ajg.2009.129 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....c8e227788e98fd37b1645d44754aa591 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15720241 00029270 |
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