ZNF830 mediates cancer chemoresistance through promoting homologous-recombination repair
| العنوان: | ZNF830 mediates cancer chemoresistance through promoting homologous-recombination repair |
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| المؤلفون: | Xiaorui Shi, Liqian Zhou, Tongyu Li, Wei Liu, Hangxiang Wang, Tian Xie, Jianqin Wan, Xu Liu, Yiting Qiao, Guo Chen, Yaru Shi, Fu Wang, Qi Zeng, Hui Xie, Jianxiang Chen, Youwei Sun |
| المصدر: | Nucleic Acids Research |
| بيانات النشر: | Oxford University Press (OUP), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Genome instability, Lung Neoplasms, DNA damage, Kruppel-Like Transcription Factors, Regulator, Mice, Nude, Antineoplastic Agents, Ataxia Telangiectasia Mutated Proteins, Genome Integrity, Repair and Replication, Biology, Genomic Instability, Mice, 03 medical and health sciences, chemistry.chemical_compound, Stomach Neoplasms, Cell Line, Tumor, Genetics, medicine, Animals, Humans, Hydroxyurea, DNA Breaks, Double-Stranded, Phosphorylation, Zinc finger, Binding Sites, Endodeoxyribonucleases, Osteoblasts, Nuclear Proteins, Recombinational DNA Repair, Cancer, Epithelial Cells, DNA, Neoplasm, medicine.disease, Survival Analysis, Xenograft Model Antitumor Assays, 030104 developmental biology, chemistry, Drug Resistance, Neoplasm, Cancer cell, Cancer research, Camptothecin, Female, Carrier Proteins, Homologous recombination, DNA, Protein Binding |
| الوصف: | Homologous recombination (HR), which mediates the repair of DNA double-strand breaks (DSB), is crucial for maintaining genomic integrity and enhancing survival in response to chemotherapy and radiotherapy in human cancers. However, the mechanisms of HR repair in treatment resistance for the improvement of cancer therapy remains unclear. Here, we report that the zinc finger protein 830 (ZNF830) promotes HR repair and the survival of cancer cells in response to DNA damage. Mechanistically, ZNF830 directly participates in DNA end resection via interacting with CtIP and regulating CtIP recruitment to DNA damage sites. Moreover, the recruitment of ZNF830 at DNA damage sites is dependent on its phosphorylation at serine 362 by ATR. ZNF830 directly and preferentially binds to double-strand DNA with its 3′ or 5′ overhang through the Zinc finger (Znf) domain, facilitating HR repair and maintaining genome stability. Thus, our study identified a novel function of ZNF830 as a HR repair regulator in DNA end resection, conferring the chemoresistance to genotoxic therapy for cancers those that overexpress ZNF830. |
| تدمد: | 1362-4962 0305-1048 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f282f33bdff15d61abf794519f2764 https://doi.org/10.1093/nar/gkx1258 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c8f282f33bdff15d61abf794519f2764 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13624962 03051048 |
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