The Causes of Gastroesophageal Reflux after Laparoscopic Sleeve Gastrectomy: Quantitative Assessment of the Structure and Function of the Esophagogastric Junction by Magnetic Resonance Imaging and High-Resolution Manometry
| العنوان: | The Causes of Gastroesophageal Reflux after Laparoscopic Sleeve Gastrectomy: Quantitative Assessment of the Structure and Function of the Esophagogastric Junction by Magnetic Resonance Imaging and High-Resolution Manometry |
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| المؤلفون: | Bernard Dallemagne, Giuseppe Quero, Silvana Perretta, Pietro Mascagni, Jelena Curcic, Claudio Fiorillo, Mark A. Fox |
| المساهمون: | University of Zurich, Fiorillo, Claudio |
| المصدر: | Obesity Surgery. 30:2108-2117 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Manometry, Settore MED/18 - CHIRURGIA GENERALE, Endocrinology, Diabetes and Metabolism, Magnetic Resonance Imaging (MRI), 610 Medicine & health, 030209 endocrinology & metabolism, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Gastrectomy, Internal medicine, medicine, Humans, Obesity, Morbid, Esophagogastric junction, High resolution manometry, Laparoscopic sleeve gastrectomy, Nutrition and Dietetics, medicine.diagnostic_test, business.industry, Stomach, Laparoscopic Sleeve Gastrectomy, Reflux, Magnetic resonance imaging, GERD, Middle Aged, medicine.disease, Magnetic Resonance Imaging, digestive system diseases, 2746 Surgery, Obesity, Morbid, 2712 Endocrinology, Diabetes and Metabolism, 10219 Clinic for Gastroenterology and Hepatology, medicine.anatomical_structure, Ambulatory, Gastroesophageal Reflux, 2916 Nutrition and Dietetics, Laparoscopy, 030211 gastroenterology & hepatology, Surgery, Esophagogastric Junction, business |
| الوصف: | The incidence of de novo gastroesophageal reflux disease (GERD) after LSG is substantial. However, an objective correlation with the structural gastric and EGJ changes has not been demonstrated yet. We aimed to prospectively evaluate the effects of laparoscopic sleeve gastrectomy (LSG) on the structure and function of the esophagogastric junction (EGJ) and stomach. Investigations were performed before and after > 50% reduction in excess body weight (6–12 months after LSG). Subjects with GERD at baseline were excluded. Magnetic Resonance Imaging (MRI), high-resolution manometry (HRM), and ambulatory pH-impedance measurements were used to assess the structure and function of the EGJ and stomach before and after LSG. From 35 patients screened, 23 (66%) completed the study (age 36 ± 10 years, BMI 42 ± 5 kg/m2). Mean excess weight loss was 59 ± 18% after 7.1 ± 1.7-month follow-up. Esophageal acid exposure (2.4 (1.5–3.2) to 5.1 (2.8–7.3); p = 0.040 (normal 80% reduction in gastric capacity (TGV) had the highest prevalence of symptomatic GERD. LSG has multiple effects on the EGJ and stomach that facilitate reflux. In particular, EGJ disruption as indicated by increased (more obtuse) esophagogastric insertion angle and small gastric capacity were associated with the risk of GERD after LSG. : NCT01980420 |
| تدمد: | 1708-0428 0960-8923 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90df28055e455db0fd7fb8ad7d7597a https://doi.org/10.1007/s11695-020-04438-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....c90df28055e455db0fd7fb8ad7d7597a |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 17080428 09608923 |
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