EGFR and KRAS Mutations in Lung Parenchyma of Subjects With EGFR/KRAS Wild-Type Lung Adenocarcinoma
| العنوان: | EGFR and KRAS Mutations in Lung Parenchyma of Subjects With EGFR/KRAS Wild-Type Lung Adenocarcinoma |
|---|---|
| المؤلفون: | María Teresa Rodrigo-Calvo, Roberto Chalela, Karys Khilzi, Beatriz Bellosillo, Raquel Longarón, Joaquim Gea, Albert Sánchez-Font, Jose Gregorio González-García, Clara Martín-Ontiyuelo, Víctor Curull |
| المصدر: | Pathology and Oncology Research Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Cancer Research, Lung Neoplasms, 030204 cardiovascular system & hematology, medicine.disease_cause, EGFR–epidermal growth factor receptor, Exon, 0302 clinical medicine, adenocacinoma lung, Aged, 80 and over, 05 social sciences, General Medicine, Middle Aged, Brief Research Report, Prognosis, Primary tumor, ErbB Receptors, Society Journal Archive, medicine.anatomical_structure, Oncology, Adenocarcinoma, Female, KRAS, Adenocarcinoma of Lung, Pathology and Forensic Medicine, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, 0502 economics and business, Parenchyma, medicine, Biomarkers, Tumor, Humans, Parenchymal Tissue, Aged, EGFR-epidermal growth factor receptor, Lung, business.industry, driver mutation, Wild type, Driver mutation, medicine.disease, respiratory tract diseases, Case-Control Studies, Mutation, Cancer research, Adenocacinoma lung, 050211 marketing, business, Carcinogenesis, Follow-Up Studies |
| الوصف: | The acquisition of driver mutations in non-tumoral cells appears to be very important during the carcinogenesis of adenocarcinoma (ADC). Recent studies suggest that cancer-related mutations may not necessarily be present only in malignant cells, but also in histologically “healthy cells”.Objective: to demonstrate the presence of EGFR or KRAS mutations in non-tumoral lung cells in subjects with ADC and negative mutational status.Results: mutations in EGFR or KRAS oncogenes were identified in the normal lung in 9.7% of the subjects. Exon 21 substitution L858R in EGFR was detected in two cases while the exon 19 deletion E746-A750 in the EGFR, the G12C and G12D substitutions in the KRAS were detected once. One patient presented three different mutations in the normal lung parenchyma (EGFR_L858R, KRAS_G12C and KRAS_G12D). The negative-mutation status of the tumor and the mutations detected in the “normal lung” were confirmed using highly sensitive and specific TaqMan PCR (CAST-PCR). No differences were found in terms of progression, progression-free survival or overall survival during the 18 months follow-up.Conclusions: These results confirm the presence of driver mutations in the histologically normal lung parenchyma cells in the absence of mutations coexisting with the primary tumor. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c957cf5e27bfd158703fa17ee259ff12 https://ddd.uab.cat/record/248155 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c957cf5e27bfd158703fa17ee259ff12 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |