Lack of association between the CCR5-delta32 polymorphism and neurodegenerative disorders
| العنوان: | Lack of association between the CCR5-delta32 polymorphism and neurodegenerative disorders |
|---|---|
| المؤلفون: | Anna Karydas, Jennifer S. Yokoyama, Eliana Marisa Ramos, Ariane H. Ayer, Giovanni Coppola, Bruce L. Miller, Suzee E. Lee, Adam L. Boxer, Joel H. Kramer, Kevin Wojta, Peter D. Nguyen |
| المصدر: | Alzheimer Dis Assoc Disord Alzheimer disease and associated disorders, vol 34, iss 3 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Aging, viruses, Disease, Neurodegenerative, Bioinformatics, California, Cohort Studies, neurodegenerative disease, 0302 clinical medicine, Receptors, 2.1 Biological and endogenous factors, 030212 general & internal medicine, Aetiology, Age of Onset, Receptor, Neurodegeneration, virus diseases, Neurodegenerative Diseases, Middle Aged, Psychiatry and Mental health, Clinical Psychology, Neurological, Cohort, Cognitive Sciences, Adult, Receptors, CCR5, Clinical Sciences, association study, Article, Frameshift mutation, 03 medical and health sciences, Genetic, Genetics, medicine, Humans, Polymorphism, Allele, Alleles, Polymorphism, Genetic, business.industry, genetic variants, Neurosciences, medicine.disease, Geriatrics, Synaptic plasticity, Geriatrics and Gerontology, Age of onset, business, CCR5, Gerontology, 030217 neurology & neurosurgery, dementia |
| الوصف: | OBJECTIVE Recent studies have suggested that diminished Ccr5 functioning has an effect on synaptic plasticity and hippocampal memory in mouse models. CCR5-delta32, a 32-bp frameshift deletion in human CCR5 encoding a nonfunctional receptor, has been reported to have a protective effect against human immunodeficiency virus infection but its role as a modifier of neurodegenerative disease has been minimally explored. We investigated whether the CCR5-delta32 polymorphism could have an effect in the context of human neurodegenerative diseases. METHODS We examined the frequency of the CCR5-delta32 polymorphism in a large and well-characterized cohort including 1425 patients with neurodegenerative dementias and 2032 controls. RESULTS We did not observe a significant association between the CCR5-delta32 polymorphism and any of the neurodegenerative diseases screened in this study. However, we observed an earlier age of onset among neurodegenerative disease patients carrying the CCR5-delta32 allele. CONCLUSIONS Although our findings were inconclusive, the earlier age of onset observed among neurodegenerative disease patients carrying the CCR5-delta32 allele suggests that the deletion may have a detrimental effect in the context of neurodegeneration. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96df13d42617ffa1efb3e346f89df9d https://europepmc.org/articles/PMC7365743/ |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c96df13d42617ffa1efb3e346f89df9d |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |