Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers
| العنوان: | Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers |
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| المؤلفون: | Yuk Y. Sham, Evelyne M. Houang, Frank S. Bates, Joseph M. Metzger |
| المصدر: | Skeletal Muscle Skeletal Muscle, Vol 8, Iss 1, Pp 1-19 (2018) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Duchenne muscular dystrophy, lcsh:Diseases of the musculoskeletal system, Systems biology, Poloxamer, Review, 03 medical and health sciences, 0302 clinical medicine, Sarcolemma, Membrane stabilization, medicine, Copolymer, Animals, Humans, Orthopedics and Sports Medicine, Muscle membrane, Molecular Biology, Clinical Trials as Topic, Cell Biology, medicine.disease, Block copolymers, Chemical space, 3. Good health, Muscular Dystrophy, Duchenne, 030104 developmental biology, Membrane, Biophysics, lcsh:RC925-935, 030217 neurology & neurosurgery |
| الوصف: | The scientific premise, design, and structure-function analysis of chemical-based muscle membrane stabilizing block copolymers are reviewed here for applications in striated muscle membrane injury. Synthetic block copolymers have a rich history and wide array of applications from industry to biology. Potential for discovery is enabled by a large chemical space for block copolymers, including modifications in block copolymer mass, composition, and molecular architecture. Collectively, this presents an impressive chemical landscape to leverage distinct structure-function outcomes. Of particular relevance to biology and medicine, stabilization of damaged phospholipid membranes using amphiphilic block copolymers, classified as poloxamers or pluronics, has been the subject of increasing scientific inquiry. This review focuses on implementing block copolymers to protect fragile muscle membranes against mechanical stress. The review highlights interventions in Duchenne muscular dystrophy, a fatal disease of progressive muscle deterioration owing to marked instability of the striated muscle membrane. Biophysical and chemical engineering advances are presented that delineate and expand upon current understanding of copolymer-lipid membrane interactions and the mechanism of stabilization. The studies presented here serve to underscore the utility of copolymer discovery leading toward the therapeutic application of block copolymers in Duchenne muscular dystrophy and potentially other biomedical applications in which membrane integrity is compromised. |
| تدمد: | 2044-5040 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9aad2b29f99ca3730917cb3448f6d8d https://pubmed.ncbi.nlm.nih.gov/30305165 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c9aad2b29f99ca3730917cb3448f6d8d |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20445040 |
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