Characterisation of 22446 patients attending UK emergency departments with suspected COVID-19 infection: Observational cohort study

التفاصيل البيبلوغرافية
العنوان: Characterisation of 22446 patients attending UK emergency departments with suspected COVID-19 infection: Observational cohort study
المؤلفون: Jose Schutter, Ben Thomas, Kirsty Challen, Elena Sheldon, Ian Maconochie, Sarah Connelly, Jamie Hall, Darren Walter, Chris Fitzsimmons, Tim Harris, Katie Biggs, Steve Goodacre, Richard Simmonds, Laura Sutton, Emma Young, Fiona Lecky, Simon Waterhouse, Ellen Lee, Andrew Lee, Carl Marincowitz, Amanda Loban, Andrew Bentley
المصدر: medRxiv
بيانات النشر: Cold Spring Harbor Laboratory, 2020.
سنة النشر: 2020
مصطلحات موضوعية: High rate, medicine.medical_specialty, Poor prognosis, Coronavirus disease 2019 (COVID-19), Lung disease, business.industry, Internal medicine, medicine, Emergency department, business, Cohort study
الوصف: BackgroundHospital emergency departments play a crucial role in the Initial management of suspected COVID-19 infection. We aimed to characterise patients attending emergency departments with suspected COVID-19, including subgroups based on sex, ethnicity and COVID-19 test results.MethodsWe undertook a mixed prospective and retrospective observational cohort study in 70 emergency departments across the United Kingdom (UK). We collected presenting data from 22446 people attending with suspected COVID-19 between 26 March 2020 and 28 May 2020. Outcomes were admission to hospital, COVID-19 result, organ support (respiratory, cardiovascular or renal), and death, by record review at 30 days.ResultsAdults were acutely unwell (median NEWS2 score 4) and had high rates of admission (67.1%), COVID-19 positivity (31.2%), organ support (9.8%) and death (15.9%). Children had much lower rates of admission (27.4%), COVID-19 positivity (1.2%), organ support (1.4%) and death (0.3%). Adult men and women presented in similar numbers (10210 versus 10506), but men were more likely to be admitted (72.9% v 61.4%), require organ support (12.2% v 7.7%) and die (18.7% v 13.3%). Black or Asian adults tended to be younger than White adults (median age 54, 50 and 67 years), were less likely to be admitted (60.8%, 57.3%, 69.6%) or die (11.9%, 11.2%, 16.8%), but were more likely to require organ support (15.9%, 14.3%, 8.9%) or have a positive COVID-19 test (40.8%, 42.1%, 30.0%). Adults admitted with confirmed COVID-19 had similar age and comorbidities (except chronic lung disease) to those who did not have COVID-19 confirmed, but were much more likely to need organ support (22.2% v 8.9%) or die (32.7% v 15.9%).ConclusionsImportant differences exist between patient groups presenting to the emergency department with suspected COVID-19. People with confirmed COVID-19 have a poor prognosis, compared with similar emergency admissions without confirmed COVID-19.RegistrationISRCTN registry, ISRCTN56149622, http://www.isrctn.com/ISRCTN28342533
وصف الملف: application/pdf
اللغة: English
DOI: 10.1101/2020.08.10.20171496
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d7047668513cd9800a69635bc3b431
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....c9d7047668513cd9800a69635bc3b431
قاعدة البيانات: OpenAIRE
الوصف
DOI:10.1101/2020.08.10.20171496