Kidney biopsy in AA amyloidosis: impact of histopathology on prognosis
| العنوان: | Kidney biopsy in AA amyloidosis: impact of histopathology on prognosis |
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| المؤلفون: | Kenan Keven, Neval Duman, Arzu Ensari, Kenan Ates, Serkan Akturk, Bengi Ozturk, Zeynep Kendi Celebi, Sehsuvar Erturk, Sule Sengul, Siyar Erdogmus, Sim Kutlay, Saba Kiremitci, Gokhan Nergizoglu |
| المصدر: | Amyloid. 24:176-182 |
| بيانات النشر: | Informa UK Limited, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, Amyloid, medicine.medical_specialty, Pathology, Biopsy, Kidney Glomerulus, 030232 urology & nephrology, Renal function, End stage renal disease, 03 medical and health sciences, 0302 clinical medicine, AA amyloidosis, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Aged, Retrospective Studies, Kidney, medicine.diagnostic_test, urogenital system, business.industry, Amyloidosis, Middle Aged, Prognosis, medicine.disease, medicine.anatomical_structure, Renal pathology, Female, Histopathology, business, Glomerular Filtration Rate |
| الوصف: | In AA amyloidosis, while kidney biopsy is widely considered for diagnosis by clinicians, there is no evidence that the detailed investigation of renal histopathology can be utilized for the prognosis and clinical outcomes. In this study, we aimed to obtain whether histopathologic findings in kidney biopsy of AA amyloidosis might have prognostic and clinical value. This is a retrospective cohort study that included 38 patients who were diagnosed with AA amyloidosis by kidney biopsy between 2005 and 2013.The kidney biopsy specimens of patients were evaluated and graded for several characteristics of histopathological lesions and their relationship with renal outcomes. Segmental amyloid deposition in the kidney biopsy was seen in 29%, global amyloid deposition in 71, diffuse involvement of glomeruli in 84.2%, focal involvement in 7%, glomerular enlargement in 53%, tubular atrophy in 75% and interstitial fibrosis in 78% of patients. Histopathologically, glomerular enlargement, interstitial fibrosis, tubular atrophy, interstitial inflammation and global amyloid deposition were significantly associated with lower estimated glomerular filtration rate (eGFR) (p = .02, p |
| تدمد: | 1744-2818 1350-6129 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d8375377b3e01c4a42777b99f5469f https://doi.org/10.1080/13506129.2017.1350158 |
| رقم الأكسشن: | edsair.doi.dedup.....c9d8375377b3e01c4a42777b99f5469f |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17442818 13506129 |
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