Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis
| العنوان: | Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis |
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| المؤلفون: | Jiyao Song, Thomas Becker, Lena-Sophie Wenz, Silke Oeljeklaus, Łukasz Opaliński, Bettina Warscheid, Nikolaus Pfanner, Chantal Priesnitz |
| المصدر: | Cell Reports, Vol 25, Iss 8, Pp 2036-2043.e5 (2018) Cell Reports |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Saccharomyces cerevisiae Proteins, TIM/TOM complex, Saccharomyces cerevisiae, Mitochondrion, medicine.disease_cause, Article, General Biochemistry, Genetics and Molecular Biology, Substrate Specificity, Mitochondrial Proteins, 03 medical and health sciences, Cytosol, Protein Domains, TOM complex, Mitochondrial Precursor Protein Import Complex Proteins, Protein targeting, protein targeting, medicine, Translocase, Receptor, lcsh:QH301-705.5, biology, Chemistry, cytosolic chaperones, Mitochondria, Cell biology, 030104 developmental biology, lcsh:Biology (General), Protein Biosynthesis, biology.protein, Carrier Proteins, Bacterial outer membrane, Biogenesis, J-proteins |
| الوصف: | Summary Mitochondria possess elaborate machineries for the import of proteins from the cytosol. Cytosolic factors like Hsp70 chaperones and their co-chaperones, the J-proteins, guide proteins to the mitochondrial surface. The translocase of the mitochondrial outer membrane (TOM) forms the entry gate for preproteins. How the proteins are delivered to mitochondrial preprotein receptors is poorly understood. We identify the cytosolic J-protein Xdj1 as a specific interaction partner of the central receptor Tom22. Tom22 recruits Xdj1 to the mitochondrial surface to promote import of preproteins and assembly of the TOM complex. Additionally, we find that the receptor Tom70 binds a different cytosolic J-protein, Djp1. Our findings suggest that cytosolic J-proteins target distinct TOM receptors and promote the biogenesis of mitochondrial proteins. Graphical Abstract Highlights • The receptor Tom22 recruits the cytosolic J-protein Xdj1 to mitochondria • Xdj1 delivers preproteins to Tom22 and promotes biogenesis of the TOM complex • The receptor Tom70 recruits a different cytosolic J-protein, Djp1 • Mitochondrial receptors selectively recognize cytosolic J-protein co-chaperones Opaliński et al. report that mitochondrial protein import receptors selectively recognize J-protein co-chaperones of the cytosol. The co-chaperones bind hydrophobic precursor proteins and assist in transferring them to the receptors of the mitochondrial protein entry gate. |
| اللغة: | English |
| تدمد: | 2211-1247 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f532589ce9eb608656d68978d3d960 http://www.sciencedirect.com/science/article/pii/S2211124718316875 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c9f532589ce9eb608656d68978d3d960 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22111247 |
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