The effect of diet‐induced obesity and pasture on blood pressure and serum cortisol in Standardbred mares
| العنوان: | The effect of diet‐induced obesity and pasture on blood pressure and serum cortisol in Standardbred mares |
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| المؤلفون: | Sanna Lindåse, Ellen Winqvist, Katarina Nostell, J. Bröjer |
| المصدر: | Equine Veterinary Journal. 53:542-548 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Hydrocortisone, Blood Pressure, Pasture, Energy requirement, Animal science, Insulin resistance, Animals, Insulin, Medicine, Horses, Obesity, geography, geography.geographical_feature_category, business.industry, Horse, General Medicine, medicine.disease, Diet, Blood pressure, Female, Horse Diseases, medicine.symptom, business, Weight gain, Serum cortisol |
| الوصف: | Background Obesity is associated with insulin resistance, vascular dysfunction and altered cortisol metabolism both in humans and in horses. Objectives Evaluate the effect of weight gain induced by a haylage diet low in nonstructural carbohydrates (NSC) on insulin sensitivity, blood pressure and serum cortisol concentrations. Study design In vivo experiment. Methods Nine adult Standardbred mares fed a fat supplemented haylage diet at 250% of the horses' daily metabolisable energy requirements for 22 weeks. Horses were then turned out on pasture for 4 weeks. Insulin sensitivity (SICLAMP ) was measured before and after weight gain and after 4 weeks of pasture using the euglycemic hyperinsulinaemic clamp (EHC) method. Body condition score (BCS), blood pressure and serum cortisol were monitored throughout the study. All data were analysed using the linear mixed model procedure. Values of P Results All horses became obese during the weight gain period (BCS> 7). Mean arterial blood pressure (MAP) increased during the weight gain period and was significantly higher than initial values at the end of the weight gain period (78 ± 3 mm Hg vs 92 ± 3 mmHg). MAP remained increased on pasture (93 ± 3 mmHg). SICLAMP was unaffected by weight gain 0.9 ± 0.1 vs 1.0 ± 0.1 ([mg/kg/min × 103 ]/[µIU/mL × mmol/L])) but improved after pasture (1.6 ± 0.1 ([mg/kg/min × 103 ]/ [mU/L]). Serum cortisol concentrations increased during the weight gain period (80 ± 9 nmol/L vs 112 ± 9 nmol/L) and remained increased during pasture. Main limitations Limited number of horses and no control group. Conclusions Obesity was associated with a linear increase in blood pressure and an increase in serum cortisol that was not associated with insulin sensitivity. |
| تدمد: | 2042-3306 0425-1644 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2d5d5bc74fa7aafd7bed99baf6b22c https://doi.org/10.1111/evj.13294 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ca2d5d5bc74fa7aafd7bed99baf6b22c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20423306 04251644 |
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