Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlying hippocampal theta and gamma oscillations impaired by amyloid β oligomers in vivo
| العنوان: | Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlying hippocampal theta and gamma oscillations impaired by amyloid β oligomers in vivo |
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| المؤلفون: | Kyerl Park, Michael M. Kohl, Hyun Jae Jang, Hyowon Chung, Jeehyun Kwag |
| المصدر: | Brain Structure & Function |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Histology, Amyloid beta oligomers, Interneuron, Postsynaptic Current, Hippocampus, Parvalbumin interneuron, Optogenetics, Hippocampal formation, Inhibitory postsynaptic potential, Mice, 03 medical and health sciences, 0302 clinical medicine, Interneurons, In vivo, medicine, Animals, Gamma Rhythm, Gene Knock-In Techniques, Theta Rhythm, 030304 developmental biology, 0303 health sciences, Amyloid beta-Peptides, biology, Chemistry, musculoskeletal, neural, and ocular physiology, General Neuroscience, fungi, Alzheimer's disease, Network oscillations, Parvalbumins, medicine.anatomical_structure, nervous system, biology.protein, Somatostatin interneuron, Original Article, Anatomy, Somatostatin, Neuroscience, 030217 neurology & neurosurgery, Parvalbumin |
| الوصف: | Accumulation of amyloid β oligomers (AβO) in Alzheimer’s disease (AD) impairs hippocampal theta and gamma oscillations. These oscillations are important in memory functions and depend on distinct subtypes of hippocampal interneurons such as somatostatin-positive (SST) and parvalbumin-positive (PV) interneurons. Here, we investigated whether AβO causes dysfunctions in SST and PV interneurons by optogenetically manipulating them during theta and gamma oscillations in vivo in AβO-injected SST-Cre or PV-Cre mice. Hippocampal in vivo multi-electrode recordings revealed that optogenetic activation of channelrhodopsin-2 (ChR2)-expressing SST and PV interneurons in AβO-injected mice selectively restored AβO-induced reduction of the peak power of theta and gamma oscillations, respectively, and resynchronized CA1 pyramidal cell (PC) spikes. Moreover, SST and PV interneuron spike phases were resynchronized relative to theta and gamma oscillations, respectively. Whole-cell voltage-clamp recordings in CA1 PC in ex vivo hippocampal slices from AβO-injected mice revealed that optogenetic activation of SST and PV interneurons enhanced spontaneous inhibitory postsynaptic currents (IPSCs) selectively at theta and gamma frequencies, respectively. Furthermore, analyses of the stimulus–response curve, paired-pulse ratio, and short-term plasticity of SST and PV interneuron-evoked IPSCs ex vivo showed that AβO increased the initial GABA release probability to depress SST/PV interneuron’s inhibitory input to CA1 PC selectively at theta and gamma frequencies, respectively. Our results reveal frequency-specific and interneuron subtype-specific presynaptic dysfunctions of SST and PV interneurons’ input to CA1 PC as the synaptic mechanisms underlying AβO-induced impairments of hippocampal network oscillations and identify them as potential therapeutic targets for restoring hippocampal network oscillations in early AD. Electronic supplementary material The online version of this article (10.1007/s00429-020-02044-3) contains supplementary material, which is available to authorized users. |
| وصف الملف: | application/pdf |
| تدمد: | 1863-2661 1863-2653 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca43038dcae5d8caf77719c8b4d7322c https://doi.org/10.1007/s00429-020-02044-3 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ca43038dcae5d8caf77719c8b4d7322c |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 18632661 18632653 |
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