Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos
| العنوان: | Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos |
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| المؤلفون: | Ravi Shankar Goutam, Unjoo Lee, Soochul Park, Jaebong Kim, Vijay Kumar |
| المصدر: | Cells, Vol 10, Iss 2148, p 2148 (2021) Cells |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cell signaling, QH301-705.5, Gene regulatory network, Context (language use), Germ layer, Review, Biology, Fibroblast growth factor, Models, Biological, Transcriptional regulation, Animals, Humans, FGF, Biology (General), Cell growth, FGFR, embryonic patterning, Gene Expression Regulation, Developmental, General Medicine, Receptors, Fibroblast Growth Factor, Cell biology, Fibroblast Growth Factors, germ layer formation, Fibroblast growth factor receptor, embryonic development, Vertebrates, transcription regulation, Germ Layers, Protein Binding, Signal Transduction |
| الوصف: | Fibroblast growth factors (FGFs) comprise a large family of growth factors, regulating diverse biological processes including cell proliferation, migration, and differentiation. Each FGF binds to a set of FGF receptors to initiate certain intracellular signaling molecules. Accumulated evidence suggests that in early development and adult state of vertebrates, FGFs also play exclusive and context dependent roles. Although FGFs have been the focus of research for therapeutic approaches in cancer, cardiovascular disease, and metabolic syndrome, in this review, we mainly focused on their role in germ layer specification and axis patterning during early vertebrate embryogenesis. We discussed the functional roles of FGFs and their interacting partners as part of the gene regulatory network for germ layer specification, dorsal–ventral (DV), and anterior-posterior (AP) patterning. Finally, we briefly reviewed the regulatory molecules and pharmacological agents discovered that may allow modulation of FGF signaling in research. |
| اللغة: | English |
| تدمد: | 2073-4409 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca48afa2277b04b6a339bf6f22f42ce4 https://www.mdpi.com/2073-4409/10/8/2148 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ca48afa2277b04b6a339bf6f22f42ce4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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