Excess Mortality in Acromegaly
| العنوان: | Excess Mortality in Acromegaly |
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| المؤلفون: | I.M. Holdaway |
| المصدر: | Hormone Research in Paediatrics. 68:166-172 |
| بيانات النشر: | S. Karger AG, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | medicine.medical_specialty, Time Factors, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Growth hormone, Endocrinology, Predictive Value of Tests, Risk Factors, Cause of Death, Internal medicine, Acromegaly, Humans, Medicine, In patient, Insulin-Like Growth Factor I, Radiation Injuries, Excess mortality, Human Growth Hormone, business.industry, Growth factor, medicine.disease, Cardiovascular Diseases, Hypertension, Pediatrics, Perinatology and Child Health, business |
| الوصف: | Background: Increased production of growth hormone (GH) and insulin-like growth factor-I (IGF-I) in patients with acromegaly is associated with a twofold increase in mortality compared with the general population. The range of standardised mortality rates in various studies ranges from 1.2 to 3.6. Predictors of Mortality: Multivariate analysis has indicated that post-treatment serum GH levels and, in a number of studies, serum IGF-I levels are the most powerful predictors of outcome. Normal IGF-I concentrations and random GH levels Conclusions: Analysis of recent reports suggests that adoption of treatment guidelines with appropriate post-treatment target ranges for GH and IGF-I, together with the availability of newer methods to control GH oversecretion, has significantly improved patient outcomes. |
| تدمد: | 1663-2826 1663-2818 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4975567a705e18a49ce4af3856bac6 https://doi.org/10.1159/000110617 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ca4975567a705e18a49ce4af3856bac6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16632826 16632818 |
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